VEGF诱导胃癌细胞上皮间质转化的相关信号通路的研究
被引量:1
摘要
上皮间质转化(epithelial-to-mesenchymal transitions,EMT)是指具有极性的上皮细胞转换成具有活动能力、能够在细胞基质间自由移动的间充质细胞过程。这一转化过程涉及到了调节肿瘤的生长、浸润、转移、血管的生成和上皮细胞、间质细胞标记物的改变。EMT机制的研究对肿瘤的进展、病人的预后、常规抗肿瘤药物的耐药等方面均有重要意义。
出处
《当代医学》
2011年第10期25-26,共2页
Contemporary Medicine
参考文献11
-
1Egle AvizJenyte, Valerie G. Brunton, Valerie J. Fincham, et al.The Src-lnduced Mesenchymal Stare in Late-Stage Colon Cancer Cells[J]. Cells Tissues Organs, 2005, 179(1-2): 75-80.
-
2Avizienyte E, Frame MC. Src and FAK signalling controls adhesionfate and the epithelial-to-mesenchymal transition[J]. Curr Opin Cell Biol, 2005,17(5):542-547.
-
3Patricio Godoy, Jan G. Hengstler, lryna Ilkavets,etaI.Extracellular Matrix Modulates Sensitivity of Hepatocytes to Fibroblastoid Dedifferentiation andTransforming Growth Factorb51nduced Apoptosis[J]. HEPAYOLOGY, 2009, 49(6):2051-2045.
-
4Carla Cicchini, llaria Laudadio, Franca Citarella,et aI.TGFB--induced EMT requires foc&l &dhesion kin&se(FAK) signaling[J]. Experimental Cell Pesearch, 2008,514 :143-152.
-
5Mich e le S. Molecular signature and therapeutic perspective of thepithelial-to-mesenchymal transitions in epithelial cancers[J]. Drug Pesistance Updates, 2008,1 1(4):125-151.
-
6Carnero Amancio, Blanco-Aparicio Carmen, Eenner Oliver, et al.The PTEN/PISK/AKT Signalling Pathway in Cancer, Therapeutic Implications[J]. Current Cancer Drug Targets,2008,8(5):187-198.
-
7Suer S, Ampasala D, Walsh MF,et al. R, ole of EgK/mTOEsignaHng in TGFbeta-modulated focal adhesion kinase mENA stability and protein synthesis in cultured rat lEO-6 intestinal epithelial cells[J].Cell Tissue aes, 2009,336(2): 213-223.
-
8Binhua P. Zhou, Jiong Deng, Weiya Xia, et al. MehmetOunduz a Mien-Ghie Hung.Daual regulation of Snail by GSK-5 D-mediatedphosphoryiation in control of epithelial mesenchymal transition[J].Nature Cell Biology, 2004,6:931-940.
-
9Jong In Yook, Xiao Yah Li, Ichiro Ota, et al.A Wnt Axin2GSK5B cascade regulates Snafll activity in breast csncer cells[J]. Nature Cell Biology,2006, 8:1598-1406.
-
10Yadi Wu, Jiong Deng, Piotr G. et aI.Stabilization of Snail byNF--K B Is Pequired for Inflammation-Induced Cell Migration and Invasion[J]. Cancer Cell, 2009,15(5):416-428.
同被引文献14
-
1朱华锋,汪春兰,赵宇.VEGF和FGF-2在血管生成中的协同作用研究进展[J].中华整形外科杂志,2006,22(1):72-75. 被引量:20
-
2Weidner N.Tumoural vascularity as a prognostic factor in cancer patients:the evidence continues to grow,1998(02).
-
3Nesbit M.Abrogation of tumor vasculature using gene therapy,2000(1/2).
-
4Folkman J.Tumor angiogenesis:therapeutic implications,1971(21).
-
5Ip S P;Ko K M.The crucial antioxidant action of schisandrin B in protecting against carbon tetracb.loride hepatotoxicity in mice:a comparative study with butylated hydroxytoluene,1996(11).
-
6Yancopoulos G D;Davis S;Gale N W.Vascular-specific growth factors and blood vessel formation,2000(6801).
-
7Namiki A;Brogi E;Kearney M.Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells,1995(52).
-
8Saphir A.Angiogenesis:the unifying concept in cancer,1997(22).
-
9Thiery J P.Epithelial-mesenchymal transitions in development and pathologies[J],2003(06).
-
10Semenza G.Signal transduction to hypoxia-inducible factor 1[J],2002(5/6).
-
1常志刚,田孝东,杨尹默.胰腺癌上皮间质转化的研究现状与进展[J].中华胰腺病杂志,2013,13(2):139-142. 被引量:3
-
2王允,周清华.FHIT基因及其产物的结构和功能研究进展[J].中国肺癌杂志,2002,5(3):238-240. 被引量:1
-
3谢仰民,董辉,谢剑君,吴智勇,杜则澎,李利艳,许秀娥,周飞,陈涛,石宏顺,许丽艳,李恩民.两种食管鳞癌细胞系增殖和侵袭能力的比较研究[J].癌变.畸变.突变,2010,22(4):261-264. 被引量:3
-
4Renhu Sun Jiang Li Jing Cui Qing Lv Xinghua Liu Guobin Wang.Effect of Rapamycin on TGF-β_1-induced epithelial-mesenchymal transition in LoVo colonic adenocarcinoma cells[J].Journal of Nanjing Medical University,2009,23(1):15-19.
-
5陈金明,周海波,干建新,徐善祥,伍峻松,杨检新,周文,王沈华,易建华.胃癌RUNX3表达对凋亡与增殖细胞转换的影响及其预后价值[J].解剖学报,2008,39(4):543-546. 被引量:6
-
6YI-XIONG LEI LIAN WEI MIN WANG GEN-RONG WU MIN LI.Malignant Transformation and Abnormal Expression of Eukaryotic Initiation Factor in Bronchial Epithelial Cells Induced by Cadmium Chloride[J].Biomedical and Environmental Sciences,2008,21(4):332-338. 被引量:7
-
7朱庆超,秦环龙.上皮细胞间质转化在大肠癌发生发展中的研究进展[J].世界华人消化杂志,2012,20(21):1949-1956. 被引量:4
-
8孙彩霞,王海琳.妇科肿瘤转移机制中SNAIL基因的研究进展[J].国际妇产科学杂志,2010,37(4):260-263. 被引量:3
-
9冯芸,唐旭东.ZEB1在肺癌上皮-间质转化中作用的研究进展[J].生命科学,2013,25(5):478-483. 被引量:2
-
10笪正.上皮-间质细胞转化的分子机制及其在肿瘤转移中的作用[J].中外医学研究,2011,9(29):162-164. 被引量:2