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以D-苯甘氨酸为原料的苯并咪唑类化合物的合成 被引量：3

An efficient synthesis of the benzimidazole derivative starting from D-phenylglycine
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摘要 以D-苯甘氨酸为原料,经氨基保护和羧基活化后与邻苯二胺反应,以较高产率合成了苯并咪唑类化合物.通过1 H NMR、13C NMR、IR和X射线衍射对其结构进行了表征.同时对其进行了旋光性测定,发现以D-苯甘氨酸为原料所合成的苯并咪唑类化合物发生了外消旋化作用. The coupling of the activated N-hydroxysuccinimide ester of N-Cbz-D-phenylglycine with o-phenylenediamine afforded the benzimidazole derivative in good yield.This compound was charactered by 1H NMR,13C NMR,IR,and X-ray.In addition,the benzimidazole derivative was racemized in the reaction condition.
作者 艾林 郭胜男 申秀民
机构地区 北京师范大学化学学院
出处 《东北师大学报（自然科学版）》 CAS CSCD 北大核心 2011年第1期101-103,共3页 Journal of Northeast Normal University(Natural Science Edition)
基金 国家自然科学基金资助项目(20602003) 北京师范大学青年基金资助项目
关键词 D-苯甘氨酸 苯并咪唑类化合物 合成 D-phenylglycine benzimidazole derivative synthesis
分类号 O621.3 [理学—有机化学]
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参考文献15

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东北师大学报（自然科学版）
2011年 第1期

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