益气养阴汤辅治对妊娠期高血压综合征肾损害患者血、尿α_1-微球蛋白及肾功能的影响

INFLUENCE OF YIQIYANGYIN DECOCTION ON SERUM AND URINARY α1-MICROGLOBULIN AND RENAL FUNCTION IN PATIENTS WITH PREGNANCY -INDUCED HYPERTENSION SYNDROME AND KIDNEY DAMAGE

目的观察采用综合疗法配以自拟中药益气养阴汤治疗妊娠高血压综合征肾损害的临床疗效,并探讨其作用机制。方法将2009年6月-2010年6月河北省迁安市中医医院妇产科收治的妊娠高血压综合征肾损害患者48例,随机分为对照组和治疗组,2组均给予解痉、降压等常规对症治疗,治疗组在此基础上加用益气养阴汤,观察治疗前后2组的临床疗效及血、尿α_1-微球蛋白(α_1-mieroglobulin,α_1-MG)、尿素氮(blood urea nitrogen,BUN)、血肌酐(serum ereatinine,Scr)的变化。结果治疗组在控制血压、改善临床症状及降低血清、尿α_1-MG、BUN、Scr等方面均好于对照组,差异有统计学意义(P<0.05)。结论综合疗法配以益气养阴汤对妊娠高血压综合征肾损害具有缓解临床症状、控制血压、保护肾功能的作用。

Objective To observe the clinical traditional chinese medicine Yiqiyangyin decoction on renal efficacy of damage in hypertension syndrome, and to explore its mechanism. Methods combined therapy together with patients with pregnancy- induced Forty - eight cases of pregnancy induced hypertension syndrome patients with renal impairment admitted from June 2009 to June 2010 were randomly divided into control group and treatment group. Two groups were given spasmolysis, antihypertensive and conventional symptomatic treatment. The Yiqiyangyin decoction was added to the treatment group. The clinical effects, blood and urinary α1-microglobulin （α1-MG）, blood urea nitrogen （BUN）, serum creatinine （Scr） were observed in the two groups before and after treatment. Results The treatment group was better than control group in blood pressure control, improving clinical symptoms and decreasing serum and urinary α1- MG, BUN, Scr and so on. There was significant difference between the two groups （ P 〈 0. 05 ）. Conclusion The combined therapy together with Yiqiyangyin decoction can relieve symptom, control blood pressure and protect renal function in patients with pregnancy- induced hypertension syndrome.