家兔圆弧青霉毒素中毒的临床与病理学观察

Observation of Clinical and Pathological Manifestation of Penicillic Acid Poinsoning in Rabbits

为探讨青霉毒素对动物的毒性作用 ,给家兔静脉注射圆弧青霉毒素 (青霉酸 ) ,对其中毒的临床与病理学进行了观察 .结果表明 ,家兔青霉酸急性中毒时 ,临床上出现体温降低 ,心率先快后慢 ,呼吸增数 ,胃肠蠕动加强 ,脱毛 ,蛋白尿和引起孕兔流产 .病理学变化主要是肾、肝和心肌细胞变性 .血液学检查出现平均红细胞 ( RBC)总数、血红蛋白 ( Hb)量显著少于健康兔 ,血液尿素氮( BUN)量明显增高 ,而血液总蛋白 ( TP)

The clinical and pathological manifestation were observed after intravenous injection of penicillic acid in rabbits. The results showed that the clinical signs were depression,emaciation,decrease of body temperature,increase and decrease of heart beat frequency,increase of breath,increase of gastrointestine peristalsis,dehair,proteinuria and abortion. Main pathological change was degeneration of kidney,liver and heart. Blood test showed that total RBC and HB were less than those of healthy rabbits significantly,contents of whole blood BUN increased,while contents of blood TP decreased notably.