慢性乙肝患者乙肝血清学标志物及生化学指标的检测及意义

Viral serological markers and biochemical indicators in chronic hepatitis B infection

目的探讨慢性病毒性乙型肝炎(简称"乙肝")患者乙肝血清标志物(HBVM)不同感染模式对血清生化指标的影响,了解肝功能损害情况,为临床治疗及预后判定提供依据。方法依据乙肝标志物HBsAg(+)、HBeAg(+)、HBcAb(+)和HBsAg(+)、HBeAb(+)、HBcAb(+)分为HBeAg阳性组和HBeAg阴性组,以研究对象中的内对照作为参照,进行丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、白蛋白(ALB)、总胆红素(TBIL)等指标检测。结果 207例慢性乙肝患者中HBeAg阳性者74例(35.75%),HBeAg阴性者73例(35.27%);ALB和TBIL的含量在正常范围内,ALT和AST在两组的含量均高于正常值,与对照组间比较差异无统计学意义(P>0.05)。结论乙肝标志物的持续存在,会引起肝脏的慢性炎症反应,临床上在治疗慢性乙肝患者及预后判断时,应结合血清生化指标与乙肝标志物,以获得较好的诊疗效果。

Objective To explore the clinical significance of viral serological markers and biochemical indicators in chronic hepatitis B infection.Methods Chronic hepatitis B patients were divided into HBeAg positive group,HBeAg negative group,and the group with other situations.The patients were measured and compared for biochemical indicators,including ALT,AST,ALB and TBIL.Results There were 74（35.75%） and 73（35.27%）HBeAg positive and negative cases among 207 chronic hepatitis B patients.The levels of ALB and TBIL were lower in the HBeAg positive and HBeAg negative patients than in the other chronic HB patients,while the levels of ALT and AST were higher in the HBeAg positive and HBeAg negative patients than in the other chronic HB patients.There were no significant differences in the tested biochemical indicators between the patients of HBeAg positive and HBeAg negative groups.Conclusion The persistence of hepatitis B markers can cause chronic inflammation of liver.The combination of HBV replication markers and biochemical indicators may serve better clinical treatment and prognosis than single application.