倍他乐克对急性冠脉综合征患者心率变异性及心律失常的影响

The effects of the Betaloc on heartrate variability of acute coronary syndrom

目的探讨倍他乐克对急性冠脉综合征患者自主神经功能的影响。方法符合该研究入选标准的急性冠脉综合征患者120例,随机分成常规治疗者为对照组(n=60),常规治疗基础上加用倍他乐克者为治疗组(n=60),从小剂量开始,缓慢增加剂量,于第4周末行24 h动态心电图检查,比较两组HRV各项时域指标和心律失常发生率。结果治疗4周后,治疗组和对照组间HRV的SDNN、SDANN、PNN50、rMSSD比较,差异有统计学意义(P<0.05),心律失常发生率少于对照组(P<0.05)。结论在常规治疗的基础上,加用倍他乐克治疗急性冠脉综合征,提高HRV,减少心律失常发生率。

Objective To explore the effects of the Betaloc on HRV（heart rate variability）of acute coronary syndrom（ACS）.Methods A total of 120 case of ACS were divided into the treatment group（n=60）with Betaloc and normal treatment group（n=60）.Began with the minimum dosage,and then increased the dosage gradually.Holter tape was performed in 120 patients at the end of the fouth weeks.After four weeks of treatment,analyzed parameters of HRV and incidence of arrhythmia before and after treatment.Results HRV parameters of the Betaloct reatment group were higher than those of the normal treatment group.There was significant difference（P〈0.05）in SDNN、SDANN、rMSSD and PNN50.Incidence of arrhythmia was obviously reduced in group B（P〈0.05）.Conclusion Based on the traditional therapy,taking Betaloc additionally to treat acute coronary syndrom can increase the HRV,incidence of arrhythmia is obviously reduced.