炎症因子与胰岛素抵抗的关系

Inflammatory factors and insulin resistance

胰岛素抵抗是糖耐量减退或糖尿病、高胰岛素血症、高血压、肥胖、高脂血症等的共同发病基础,现已成为生命科学研究的热点和难点.大量流行病学研究显示慢性亚临床炎症可能与胰岛素抵抗及2 型糖尿病的转化有关.研究显示导致胰岛素抵抗的炎症因子主要有白细胞介素6、肿瘤坏死因子α、C-反应蛋白等可介导细胞内炎症反应信号转导,干扰胰岛素信号传导通路影响胰岛素信号传导激酶活性导致胰岛素抵抗.

Insulin resistance is impaired glucose tolerance or diabetes, hyperinsu--linemia, hypertension, obesity, hyperlipidemla and other co-- morbidity based on life science research has become a hot and difficult. A large number of epidemiological studies have shown that chronic subclinical inflammation may be associated with insulin resistance and type 2 diabetes transformation related. Studies have shown that inflammation leads to insulin resistance factors, including interleukin-6, tumor necrosis factor α, C-reactive protein may be mediated signal transduction in inflammatory response, interfere with insulin signaling pathways of insulin signal transduction kinase activity lead to insulin resistance.