3.6-二芳基-5,6-二氢均三唑[3,4-b][1,3,4]噻二唑的合成及生物活性

Syntheses and Antibacterial Activity of 3,6-diaryl-5,6-dihydro-s-triazoloi[3,4-b][1,3,4]thiadiazole

研究了在Ｌ－（＋）－酒石酸存在下３－芳基４－氨基－５－巯基－１，２，４－均三唑与醛的ａｎｎｉｃｈ反应及分子内的加成反应，合成了１５个新的手性稠杂环化合物３，６－二芳基－５，６－二氢均三唑，利用ＩＲ，＾１Ｈ ＮＭＲ和ＭＳ确证了其工测试了部分化合物的生物活性。

Fifteen new chiral 3,6- diaryl -5,6- dihydro - s - triazolo [3,4-b][l,3,4] thiadiazoles have been synthesized by the Mannich reaction of 3 - aryl - 4 - amino - 5 - mercapto -1,2, 4 - triazole with various aldehydes in the presence of catalytic amounts of L - ( + ) - tartaric acid. Some compounds were found to have moderatel antibacterial activities.