ERα基因多态性与更年期焦虑抑郁发生的相关性

Correlation between polymorphism of estrogen receptor α gene and anxiety and depression during menopause

目的:探索ERa基因多态性与更年期焦虑抑郁发生的相关性。方法:收集更年期焦虑抑郁患者78例(焦虑抑郁组)和无焦虑抑郁症状的更年期妇女72例(对照组),采用限制性片段酶切基因多态性分析方法(RFLP)分析所有样本的PvuⅡ、XbaⅠ基因多态性,采用Greene更年期症状量表分析临床症状群的特征,采用心理症状评分(HAMD、HAMA)评定样本的抑郁焦虑程度,采用简易精神智力评定量表(MMSE)评定认知功能。结果:①焦虑抑郁组的MMSE评分和E2、P水平较对照组下降(P<0.01)。焦虑抑郁组Greene评分的焦虑症状群、抑郁症状群及躯体症状群与对照组相比明显增高,血管舒缩症状群明显降低(P<0.01)。②ERα基因的PvuⅡ和XbaⅠ的等位基因频率和基因型在两组中无统计学差异(P>0.05),Logistics回归分析显示,ERα基因型与各症状群无相关性。ERα基因型与MMSE的评分呈现负相关(r=0.108,P=0.033)。结论:ERα基因的PvuⅡ和XbaⅠ的等位基因与焦虑抑郁障碍的发生无相关性,ERαPvuⅡ的Pp基因型与焦虑抑郁障碍的认知功能下降相关。

Objective：To explore the correlation between polymorphism of estrogen receptor α gene and anxiety and depression during menopause. Methods：78 menopausal women with anxiety and depression（anxiety-depression group） and 72 menopausal women without anxiety and depression（control group） were selected,RFLP was used to analyze the polymorphisms of Pvu Ⅱ and Xba Ⅰ,Greene-Climacteric-Scale was used to analyze the characteristics of clinical symptoms,Psychological symptom scores（HAMD,HAMA） were used to assess the degrees of anxiety and depression,MMSE was used to assess the cognitive function. Results：The MMSE score,estrogen and progesterone levels in anxiety-depression group were significantly lower than those in control group（P〈0.01）.The scores of anxiety symptoms,depression symptoms and somatic symptoms in anxiety-depression group assessed by Greene-Climacteric-Scale were significantly higher than those in control group,the score of vasomotor symptoms decreased significantly（P〈0.01）.There was no significant difference in allele frequency and genotype of estrogen receptor α gene Pvu Ⅱ and Xba Ⅰ between the two groups（P〉0.05）.Logistic analysis showed that there was no correlation between genotype of estrogen receptor α and various symptoms;there was a negative correlation between genotype of estrogen receptor α and MMSE score（γ=0.108,P=0.033）. Conclusion：There is no correlation between Pvu Ⅱ and Xba Ⅰ allele of estrogen receptor α and occurrence of anxiety-depression disorder,Pp genotype of estrogen receptor α gene Pvu Ⅱ is related to the decrease of cognitive function of patients with anxiety-depression disorder.