美洛昔康的合成(英文)

Synthesis of Meloxicam

从糖精钠出发，经４步反应合成美洛昔康，总收率４３．５％。首次分离、纯化了甲基化反应的重要副产物，经元素分析、氢谱、质谱确定为双甲基化产物。

Starting from saccharin sodium,meloxicam was synthesized in four steps with a yield of 43.5%. A byproduct in the methylating reaction was separated,purified and determined to be of the dimethylated product for the first time.Recrystallization was taken to purify the wanted monomethylated product.