用不对称二羟基化反应合成光学纯(+)-(1R,2R)和(-)-(1S,2S)-1,2-二苯基-1,2-乙二胺

Synthesis of optically pure(+)(1R,2R)and (-)(1S,2S)1,2diphenyl1,2ethylenediamine by asymmetric dihydroxylation

以（Ｅ）－１，２－二苯基乙烯为原料，经催化不对称二羟基化反应，生成相应的对映体纯１，２－乙二醇，再分别与甲基磺酰氯和叠氮钠作用，最后催化氢化，生成光学纯１，２－乙二胺，总产率７０％。

he (E)stilbene 1 is easily converted by the catalytic asymmetric dihydroxylation to corresponding enantiomerically pure diol 2.The transformation of 2 to the mesylate 3 and subsequent nucleophilic substitution with sodium azide affords the diazide 4,which is then reduced by catalytic hydrogenation to the optically pure 1,2diamine 5.The overall yield is 70%