利用氯化锌/微孔球状硅胶色谱柱制备α-叔丁基醛酮

Convenient Preparation of a - tert - Butylated Ketones and Aldehydes by Zinc Chloride/Microporous Spherical Silica Gel Column Chromatography

在担载氯化锌的微孔球状硅胶色谱柱上,用溶有适宜配比的硅基烯醇醚/叔丁基氯的二氯甲烷溶液作流动相,再经二氯甲烷洗脱,水解等步骤处理后,可制得高收率的α-叔丁基醛酮化合物。

Using the proper silyl enol ethers and tert - butyl chloride agent with CH2Cl2 as an eluent,a - tert - butylated carbonyl compounds were conveniently prepared by column chromatography on zinc chloride coated microporous spherical silica gel in good yields.