离子与通道相互作用对NaK通道通透特性影响的研究

Effect of ion-channel interaction permeability of NaK channel

以NaK通道的三维精细结构为基础,从理论上阐述了NaK通道对钠离子、钾离子、铷离子以及钙离子的通透机理,钡离子可以作为NaK通道阻断剂的微观机理,我们的研究结果表明,通道与离子的相互作用是决定通道对不同离子选择性的基础,反映通道与离子相互作用的位能曲线是通道对不同离子通透性的外在表现.

Based on the three-dimensional structure of NaK channel,the permeabilities of the NaK channel for Na ＋,K ＋,Rb ＋,Ca2 ＋ ions and the Ba2 ＋ ion blockage mechanisms are investigated.The results show that the interaction is fundamental for determining the selectivities of the channels and the potential curve reflects the external behaviors for the permeabilities of different ions.