食管鳞癌中细胞周期素A的表达对紫杉醇疗效的影响

Effects of cyclin A expression on efficacy of treating esophageal squamous cell carcinoma with paclitaxel

目的观察化疗前食管鳞癌组织中细胞周期素A的表达对紫杉醇化疗疗效的影响。方法采用免疫组化法检查48例初治食管鳞癌组织中细胞周期素A的表达。患者接受含紫杉醇为主的方案化疗两周期后评价近期疗效,随访3年生存期。结果细胞周期素A表达阳性患者化疗有效率54.8%,高于表达阴性患者的23.5%(P<0.05)。肿瘤分期、分化程度、细胞周期素A的表达是影响食管鳞癌预后的独立因素。结论细胞周期素A表达阳性的食管鳞癌患者对紫杉醇有较高的敏感性,可以作为预测紫杉醇疗效的参考指标。

Objective To evaluate the effects of cyclin A expression on efficacy of treating esophageal squamous cell carcinoma（ESCC） with paclitaxel. Methods Expression of cyclin A was detected using immunohistochemical MaxVision method in 48 patients before chemotherapy,who were newly diagnosed with ESCC and received two cycles of paclitaxel-based chemotherapy.Short-term efficacy was evaluated and 3-year survival was followed up.Results The effectiveness rate was higher in patients with cyclin A positive than that with negative（54.8% vs. 23.5%） （P0.05）. The univariate and the Cox multivariate analysis revealed that the clinical pathological stage,degree of differentiation and cyclin A expression were the independent factors to influence the prognosis in patients with ESCC. Conclusion ESCC patients with positive cyclin A expression have more sensitivity to paclitaxel treatment,suggesting that cyclin A expression may be taken as a marker to predict the efficacy of paclitaxel.