2型糖尿病患者血浆妊娠相关蛋白A与颈动脉粥样斑块的相关性

Relationship between serum pregnancy-associated plasma protein-A and carotid plague in patients with type 2 diabetes mellitus

目的探讨2型糖尿病(T2DM)患者血清中血浆妊娠相关蛋白A(PAPP-A)与颈动脉粥样斑块的相关性。方法采用双抗体夹心酶联免疫吸附实验检测单纯T2DM(A组,30例)、T2DM合并颈动脉斑块患者(B组,30例)及正常对照者(C组,28例)血清PAPP-A水平,同时检测肿瘤坏死因子(TNF)-α、糖化血红蛋白(HbA1c)、血脂、超敏C反应蛋白(hsCRP)。结果 A、B组血清PAPP-A水平均显著高于C组(P<0.05),B组血清PAPP-A水平明显高于A组(P<0.05)。B组血清PAPP-A与TNF-α呈正相关。结论 T2DM患者血清PAPP-A与慢性炎症有关,其与TNF-α共同参与颈动脉粥样斑块的形成。

Objective To explore the relationship between pregnancy-associated plasma protein-A（PAPP-A） and carotid plague in patients with type 2 diabetes mellitus（T2DM）.MethodsSerum PAPP-A levels were measured by ELISA in 60 patients with T2DM,who were divided into group A（30 cases without carotid plague） and group B（30 cases with carotid plague）.Tumor necrosis factor（TNF）-α,glycosylated hemoglobin 1c（HbA1c）,high-sensitive C reactive protein（hsCRP） and some other metabolic variables were also determined.The results were compared to those in 28 healthy controls（group C）.Results The serum PAPP-A level was significantly higher in groups of A and B than that in group C（P0.05）,which was higher in group B than that in group A（P0.05）.Serum PAPP-A level was positively correlated with TNF-α in group B（P0.05）.Conclusion PAPP-A is positively related with chronic inflammation factors in T2DM patients with carotid plagues.Serum PAPP-A togather with TNF-α may play an important role in developing carotid plague in diabetic patients.