抑癌基因HLJ1与肿瘤的演进

HLJ1 Gene and Tumor Progression

HLJ1基因是一新发现的抑癌基因，属于Dnaj类HSP40家族，其与肿瘤的复发、转移密切相关。文章着重介绍了HLJ1通过上调STAT1、p21WAF1的表达及下调CyclinD1的表达来调控细胞周期，通过加强c．iun氨基端激酶活性和激活Caspase-3来促进紫外线诱导的癌细胞凋亡以及通过影响肌动蛋白聚合重组来改变肿瘤细胞运动和侵袭能力等。此外还有HU1对NPM1的双向调节、转录因子YY1增强HLJ1启动子活性、HU1调控钙黏蛋白E和CIM4等下游基因表达的研究。HLJ1基因在肿瘤发生发展中作用机制的阐明可为下一步的科学研究和临床应用提供新思路。

HLJ1 is a newly discovered member of DnaJ-like Hsp40 family. It＇s been proved that HLJ1 acts as a tumor suppressor and is closely associated with tumor recurrence and metastasis. This paper reviews the mechanisms how HLJ1 acts in tumorigenesis and tumor progression. It is introduced that HLJ1 modulates cell cycle by up-regulating STAT1 and p21WAF1 and down-regulating CyclinD1 expression, promotes UV-induced apoptosis by enhancing JNK activity and activating Caspase-3, and changes the motility and invasion capacity of tumor ceils by rearranging β-actin configuration. Moreover, HLJ1 was reported to functionally alter nucleophosmin, be activated by the transcription factors YY1 and activator protein 1 and influence some signal-transduetion pathways by regulating some downstream genes like E-cadherin and CD44 as well. Given the clarification of the mechanisms how HLJ1 acts in tumorigenesis and tumor progression, we can find new solutions for further research and clinical use.