Ki-67、环氧化酶-2和E-钙黏附素在脑膜瘤中的表达及临床意义

Expression of Ki - 67, cyclooxygenase - 2 and E - cadherin in meningioma and its clinical significance

目的探讨Ki－67、环氧化酶－2（COX－2）和E－钙黏附素（E—cad）在人脑膜瘤中的表达及临床意义。方法应用免疫组化SP法检测60例脑膜瘤中硒－67、COX-2、E—cad蛋白的表达情况，原位杂交方法检测COX-2mRNA、E—cadmRNA在脑膜瘤中的表达。结果Ki-67、COX-2蛋白高表达和E—cad蛋白低表达与肿瘤组织学分级、侵袭性关系密切，COX-2和E—cad表达呈负相关（r=-0．926，P〈0．05）。结论Ki～67、COX-2和E—cad与脑膜瘤的病理分级、侵袭性密切相关，三者可能相互影响，共同调节脑膜瘤的侵袭性生长，联合检测COX-2和E—cad有助于判断脑膜瘤的生物学行为及预后。

Objective To investigate the expression of Ki - 67, cyclooxygenase - 2 （ COX - 2 ） and E -cadherin （E -cad） in meningioma and its clinical significance. Methods The expressions of Ki - 67, COX - 2 and E - cad protein were detected in 60 cases of meningioma by immunohistochemistry method, and the expressions of COX - 2 mRNA and E - cad mRNA were examined by in situ hybridiza- tion. Results There was significant correlation of over - expression of Ki - 67, COX - 2 and decreased expression of E - cad with pathologic grade and invasion. There was negative correlation of the expression of COX -2 and E -cad（ r = -0. 926, P 〈0.05）. Conclusions Expressions of Ki -67, COX -2 and E -cad were significant correlated with pathologic grade and invasion. They may exert mutual effect and co - regulate the invasive growth of meningiomas. Combined detection of COX - 2 and E - cad may help to predict the prognosis of meningioma.