2型糖尿病与骨钙素的关系

Relationship between osteocalcin and type 2 diabetes mellitus

目的探讨2型糖尿病患者的骨钙素变化及影响骨钙素的相关因素分析。方法对225例2型糖尿病患者测定空腹血糖、胰岛素、糖化血红蛋白、骨钙素、身高、体重，对结果进行分析。结果骨钙素正常组的空腹血糖、胰岛素、胰岛功能高于降低组，糖化血红蛋白、体重指数、糖尿病病程低于降低组，两组比较差异无统计学意义（P〉0．05）。结论对于2型糖尿病患者，骨钙素可作为骨代谢重要指标的常规筛查项目。

Objective To investigate the changes of osteocalcin in type 2 diabetes mellitus and analyze the factors which influence osteocalcin. Methods Two hundred and twenty -five patients with type 2 diabetes mellitus were selected and the osteocalcin, the fasting blood glucose, height,weight, fasting insuline,HbA1C were measmed. Results The osteocalein normal group was higher than the osteocalcin decreased group in fasting blood glucose,fasting insuline and insuline function. While for HbA1C, BMI, the course of disease, the osteocalcin normal group was lower than the osteocalcin decreased group. Conclusions Measurement of serum osteocalcin can be used as an important index of bone metabolism in type 2 diabetes mellitus.