期刊文献+

在眼科研究中大力提倡转化医学 被引量:4

Translational medicine is advocated on the ophthalmic research in China
原文传递
导出
摘要 目的近年来,我国的眼底病基础研究取得了很大成绩,但真正能够应用临床,为临床解决问题者不多,因此,要在眼底病研究中大力提倡“转化医学”,即从“实验台走向临床”的研究。要做好这一点必须重视研究工作的原创性、研究工作的可持续性和与企业界的良好合作。由于我国资源有限,我们应该在加强临床研究的基础上,提取基础研究的课题,做好双向转化的工作,提高我国眼科基础研究的效率。 Objective In recent years,a lot of achievements on the basic research of ocular disease have been made in our country, however, among these basic research works, few were finally become a agent or device to be applied in the clinic. The concept of " translational medicine", i.e. " from bench to bedside" research should be strongly advocated to catalyze the medical applications of basic research on ocular disease. For doing better this way, we suggest to do more research work of originality, to persevere the a meaningful research work and to cooperate well with biomedical enterprise. Meanwhile, we emphasize the importance of the reverse translational way, i. e. ," from bedside to bench" not only because of the limited resources including financial resources and research facility,but also for improving the efficiency of the basic research of ocular diseases in China.
作者 陈有信
出处 《中华眼科杂志》 CAS CSCD 北大核心 2011年第3期193-195,共3页 Chinese Journal of Ophthalmology
关键词 眼底病 基础研究 转化医学 Fundus disease Basic medical research Translational medicine
  • 相关文献

参考文献9

二级参考文献45

  • 1Bringmann A,Pannicke T,Grosche J,et al.Müller cells in the healthy and diseased retina.Prog Retin Eye Res,2006,25:397-424.
  • 2Hicks D,Courtois Y.The growth and behaviour of rat retinal Müller cells in vitro:1.an improved method for isolation and culture.Exp Eye Res,1990,51:119-129.
  • 3Sarthy VP,Brodjian SJ,Dutt K,et al.Establishment and characterization of a retinal Muller cell line.Invest Ophthalmol Vis Sci,1998,39:212-216.
  • 4Tropepe V,Coles BL,Chiasson BJ,et al.Retinal stem cells in the adult mammalian eye.Science,2000,287:2032-2036.
  • 5Fimbel SM,Montgomery JE,Burket CT,et al.Regeneration of inner retinal neurons after intravitreal injection of ouabain in zebrafish.J Neurosci,2007,27:1712-1724.
  • 6Ooto S,Akagi T,Kageyama R,et al.Potential for neural regeneration after neurotoxic injury in the adult mammalian retina.Proc Natl Acad Sci USA,2004,101:13654-13659.
  • 7Abrahan CE,Insua MF,Politi LE,et al.Oxidative stress promotes proliferation and dedifferentiation of retina glial cells in vitro.J Neurosci Res,2009,87:964-977.
  • 8Das AV,Mallya KB,Zhao X,et al.Neural stem cell properties of Muller glia in the mammalian retina:regulation by Notch and Wnt signaling.Dev Biol,2006,299:283-302.
  • 9Monnin J,Morand-Villeneuve N,Michel G,et al.Production of neurospheres from mammalian Muller cells in culture.Neurosci Lett,2007,421:22-26.
  • 10Kubota A,Nishida K,Nakashima K,et al.Conversion of mammalian Müller glia cells into a neuronal lineage by in vitro aggregate.Biochem Biophys Res Commun,2006,351:514-520.

共引文献84

同被引文献72

引证文献4

二级引证文献36

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部