骨保护素和碱性成纤维细胞生长因子在牙周组织再生中的应用

Application of osteoprotegerin and basic fibroblast growth factor in periodontal regeneration

背景:利用组织工程和基因治疗技术,联合应用骨保护素和碱性成纤维细胞生长因子可以促进牙周组织修复再生,是治疗重症牙周病的新方法。目的:探讨联合应用骨保护素和碱性成纤维细胞生长因子以促进牙周组织修复再生的理论依据。方法:应用计算机检索PubMed数据库(1996/2009)和中国知网数据库(1999/2009),分别以"osteoprotegerin,basic fibroblast growth factor,tissue engineering,gene therapy,periodontal regeneration"和"骨保护素、碱性成纤维细胞生长因子、组织工程、基因治疗、牙周组织修复再生"为检索词,通过阅读标题和摘要进行初筛,排除较陈旧和重复研究文献,保留符合纳入标准的文献29篇。结果与结论:使牙槽骨、牙周膜和牙骨质获得再生,形成牙周新附着一直是口腔医学研究的热点。骨保护素是一种能阻止破骨细胞分化、促进骨形成的关键因子。碱性成纤维细胞生长因子在胚胎发育,血管生成,骨的形成和修复,促进细胞增生等有广泛的作用。2者都可促进牙周组织的修复和再生。组织工程技术和基因治疗技术的出现显著促进了牙周组织修复再生研究的发展,有选择地复合这2种生长因子促进牙周支持组织的再生和修复可成为治疗牙周病的一种新方法。

BACKGROUND：Combination of osteoprotegerin and basic fibroblast growth factor can improve periodontal regeneration applying tissue engineering and gene therapy.OBJECTIVE：To summarize theoretical basis for applying osteoprotegerin and basic fibroblast growth factor to improve periodontal regeneration.METHODS：Relevant articles in PubMed （1996-2009） and CNKI （1999-2009） were searched by computer with the key words of ＂osteoprotegerin,basic fibroblast growth factor,tissue engineering,gene therapy,periodontal regeneration＂.Articles addressing originality identification,reliability,general analysis,and high correlation were included.Exclusive criteria：repetitive and obsolescent articles.A total of 29 articles were reserved for review.RESULTS AND CONCLUSION：How to obtain periodontal regeneration and to form new attachment is constantly hot spot in oral medicine research.Osteoprotegerin is a key factor in preventing osteoclasts differentiation and promoting bone formation.Basic fibroblast growth factor has extensive effects on embryo development,vascularization,bone restoration,cellular proliferation,and so on.Tissue engineering and gene therapy motivated the studies of periodontal regeneration progress.The selection of osteoprotegerin and basic fibroblast growth factor might be a method of treating periodontal diseases.