肿瘤干细胞的耐药性与耐药机制

Drug resistance and its mechanisms of cancer stem cells

背景:肿瘤干细胞不仅与肿瘤的多药耐药性有密切的关系,而且有着复杂的多药耐药机制。目的:对肿瘤干细胞及其耐药性和耐药机制的关系进行总结,为肿瘤的临床治疗提供新的思路。方法:应用计算机检索FMJS和Pubmed西文数据库检索(2003/2010),以"cancer stem cell,multiple drug resistance,apoptosis,cell cycle"为检索词;用计算机检索万方数据库(2000/2010),CNKI数据库(2000-2010)以"肿瘤;肿瘤干细胞;多药耐药性"为关键词。共收集到中文文献56篇,外文文献372篇。排除发表时间早、重复及类似研究,纳入29篇符合标准的文献。结果与结论:对干细胞的研究帮助人们加深对肿瘤的发生、发展及转移的认识。肿瘤组织中可能存在一小部分肿瘤细胞,与正常干细胞一样具有自我更新和无限增殖的能力,但具有特殊的耐药机制。肿瘤干细胞与肿瘤的发生及治疗关系密切。但针对肿瘤干细胞复杂的多药耐药机制尚有待进一步研究。

BACKGROUND：Tumor stem cells not only associate with multidrug resistance in cancer,and have a complex multi-drug resistance OBJECTIVE：To review correlation of cancer stem cells to drug resistance and resistance mechanisms,and to provide new ideas for clinical therapy of tumor. METHODS：We searched PubMed Western database and FMJS database （2003-2010） with the key words of ＂cancer stem cell,multiple drug resistance,apoptosis,cell cycle＂. Wanfang database （2000-2010） and CNKI database （2000-2010） were searched by computer with the key words of ＂tumor,cancer stem cells,multidrug resistance＂. A total of 56 Chinese literatures,372 foreign languages literatures were collected. Published earlier,repeated and similar studies were excluded and 29 literatures were included. RESULTS AND CONCLUSION：Stem cell research helps people deepen their knowledge of tumor occurrence,development and transfer. Tumor tissues have a small part of tumor cells that have self-renewal and unlimited proliferation ability as normal stem cells,but have a special mechanism of resistance. Tumor stem cells are closely related to tumor occurrence and treatment. However,complex multi-drug resistance of cancer stem cells requires further studies.