肾上腺皮质癌9例报告

Adrenocortical Carcinoma(Report of 9 Cases)

目的:探讨肾上腺皮质癌的诊断和治疗方法。方法:回顾性分析9例肾上腺皮质癌患者的临床资料,其中男7例,女2例。年龄5个月～63岁,平均39岁。术前全部行B超及CT检查,有内分泌异常者2例,分别为Cushing syndrome及原发性醛固酮增多症。无内分泌异常者7例。结果:手术完整切除9例。术后病理检查:Ⅰ期1例;Ⅱ期4例;Ⅲ期3例;Ⅳ期1例。随访4～60个月,平均生存30个月,1例因肺部转移而术后26个月死亡,1例失去随访,其余7例均存活至今。结论:肾上腺皮质癌恶性程度较高,预后较差,根治性切除是治疗肾上腺皮质癌最有效的方法。化疗及放疗可作为术后辅助治疗。早期诊断和早期治疗可提高患者生存率。

Objective：To study the methods of diagnosis and treatment of adrenocortical carcinomao Methods： Clinical data of 9 cases of adrenocortical carcinoma were retrospectively analyzed, including 7men and 2 women, whose average were 39 years old,from 5 months to 63 years old. Radiologic evaluations were performed in all cases,including ultra-sound and CT scan. Endocrinological evaluation performed in 9 patients, hormonally active tumor diagnosed were 2 of them, which usually showed typical clinical features such as Cushing＇s syndrome and primary aldosteronism . In other 7 patients,their tumors were described as non-functional. Results： All case underwent complete resection. The pathologically,there was 2 cases of stage I ,4 of stage Ⅱ ,3 of stage Ⅲ and 1 of stage IV. The mean survival time was 30 months after the follow up from 4 months to 60 months,1 patient died of pulmonary metastasis after operation 26 months later and the remaining 7 cases were still alive. Conclusions： Adrenal cortical carcinoma is a rare malignant neoplasm with poor prognosis,surgical operation is the best way for patients, chemotherapy and radiotherapy could be assisted and useful . Early diagnosis and management could increase the survival rate.