血浆内脏脂肪素水平与2型糖尿病并颈动脉粥样硬化的相关性研究

Correlation between plasma visfatin levels and type 2 diabetes mellitus with carotid atherosclerosis

目的 探讨血浆内脏脂肪素水平与2型糖尿病患者颈动脉粥样硬化的相关性.方法 依据颈部血管彩超检查将2型糖尿病患者分为无颈动脉粥样硬化患者20例,合并颈动脉粥样硬化患者20例,正常对照20例,测量颈总动脉内中膜厚度（IMT）,同时测定血浆内脏脂肪素水平以及腰围（WC）、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、血脂、空腹胰岛素（FINS）水平.结果 T2DM并颈动脉粥样硬化患者血浆内脏脂肪素水平较NC组和T2DM组明显升高[（50.85±20.14）ng/ml vs（18.50±4.60）ng/ml,（50.85±20.14）ng/ml vs（35.52±10.18）ng/ml,F=105.983,P＜0.01],T2DM患者血浆内脏脂肪素与颈总动脉IMT（r=0.476,P＜0.01）、TG（r=0.328,P＜0.01）、WC（r=0.206,P＜0.05）]呈正相关,与HDL-C呈负相关（r=-0.298,P＜0.01）.结论 血浆内脏脂肪素与T2DM患者大血管并发症的发生发展密切相关,可能参与构成动脉粥样硬化的病理生理基础.

Objective To investigate the relationship between plasma visfatin levels and type 2 diabetes mellitus patients with carotid atherosclerosis.Methods 60 subjects were divided into 3 groups,T2DM no carotid atherosclerosis group （20 cases）,T2DM with carotid atherosclerosis group （20 cases）and normal control group （20cases）.Carotid IMT,plasma visfatin,waist circumference （WC）,fasting plasma glucose （FPG）,HbA1C,blood lipids,fasting serum insulin （FINS） were assayed or measured in all subjects.Results Plasma visfatin levels in T2DM with carotid atherosclerosis were significantly higher than those in normal control group and T2DM group [ （50.85 ± 20.14） ng/ml vs （18.50 ± 4.60） ng/ml,（50.85 ±20.14） ng/ml vs （35.52 ± 10.18） ng/ml,F = 105.983,P 〈0.01].Correlation analysis showed that plasma levels of visfatin were positively correlated with carotid IMT（r =0.476,P 〈0.01）,TG （r =0.328,P 〈0.01）,WC （r =0.206,P 〈0.05） and it was negatively correlated with HDL-C（r=-0.298,P 〈0.01）.Conclusion Plasma visfatin was correlated with the development of macrovascular complications in T2DM patients,and it might be involved in the atherosclerotic pathological and physiological basis.