川崎病患儿内脂素和血管内皮细胞钙黏蛋白的含量变化

Clinical significance of Visfatin and VE-cadherin and their association with kawasaki disease

目的 观察川崎病（KD）急性期患儿血清内脂素（visfatin）和血管内皮细胞钙黏蛋白（VE-cadherin）水平变化,探讨其与川崎病的相关性及临床意义.方法 90例川崎病患儿（KD组）与30例健康体检儿童（对照组）,采用酶联免疫吸附法（ELISA）检测血清内脂素和VE-cadherin含量,并结合临床表现进行分析.结果 川崎病组血清中VE-cadherin[（5.03±1.06）mg/L]含量明显高于对照组[（2.86±1.02）mg/L],内脂素[（32.35±4.82）μg/L]含量明显高于对照组[（16.83±4.36）μg/L],两组之比较差异均有统计学意义（t=15.23,12.47,P＜0.01）.川崎病组中冠状动脉损伤患儿血清VE-cadherin[（6.14±1.23）mg/L]含量明显高于冠状动脉正常患儿[（4.02±1.01）mg/L],内脂素[（36.61±5.22）μg/L]含量明显高于冠状动脉正常患儿[（28.16±4.67）μg/L],两组之间比较差异均有统计学意义（t=8.38,7.16,P＜0.01）;川崎病组血清内脂素和VE-cadherin含量呈正相关（r=0.65,P＜0.05）.结论 内脂素和VE-cadherin在川崎病急性期尤其伴冠状动脉病变时明显升高,可作为判断川崎病冠状动脉损伤的参考指标.

Objective To explore the levels and clinical significance of visfatin and VE-cadherin in the serum of children with Kawasaki diseases （KD）.Methods Serum levels of visfatin and VE-cadherin were measured in 90 children with KD and 30 healthy children （control group） by ELISA,the outcome was estimated in combination with clinical symptoms.Results The serum levels of visfatin [ （32.35 ± 4.82）μg/L ] and VE-cadherin[ （5.03 ± 1.06）mg/L] in children with KD were obviously higher than those in control group[ （16.83 ±4.36） μg/L,（2.86 ± 1.02） mg/L] （t = 15.23,12.47,P 〈0.01）.The serum levels of visfatin[ （36.61 ±5.22） μg/L] and VE-cadherin [ （6.14 ± 1.23） mg/L] in children with KD and CAL were obviously higher than children of KD without CAL[ （28.16 ± 4.67）g/L,（4.02 ± 1.01）mg/L] （t =8.38,7.16,P 〈0.01）.In children with KD,the serum levels of visfatin and VE-cadherin were significantly correlated （r = 0.65,P 〈 0.05）.Conclusions Serum levels of visfatin and VE-cadherin increased in the acute phase of KD,and it was significantly increased in those KD children with CAL.Visfatin and VE-cadherin may be used as an important serological indicator of KD with CAL.