138例淋巴结转移阴性胃癌患者的预后因素分析

Prognostic factors in 138 patients with node-negative gastric cancer

目的探讨淋巴结转移阴性胃癌患者的预后影响因素。方法回顾性分析天津医科大学附属肿瘤医院2000—2005年间接受根治性胃切除手术治疗．且术后病理证实为淋巴结转移阴性的138例胃癌患者的临床资料，并对预后影响因素进行单因素和多因素分析。结果本组患者5年生存率为62．4％。单因素分析结果显示，肿瘤大小、肿瘤部位、分化程度、浸润深度、胃切除方式、Lauren分型与患者预后有关（P〈0．05）；多因素分析结果显示，肿瘤大小、分化程度和浸润深度是影响预后的独立因素（P〈0．05）。结论对于接受根治性手术治疗的淋巴结转移阴性的胃癌患者，肿瘤大小、肿瘤分化程度及是否浸润浆膜是评估预后的重要指标。

Objective To investigate the risk factors for the prognosis in patients with nodenegative gastric cancer. Methods Clinicopathological characteristics of 138 patients with node-negative gastric carcinoma undergoing curative gastrectomy from January 2000 to December 2005 were retrospectively analyzed. Results The overall 5-year survival rate was 62.4%. The univariate analysis revealed that tumor size, tumor location, cell differentiation, invasive depth, operative type and Lauren histologie type had significant effects on the survival. The independent prognostic factors of these patients were tumor size, cell differentiation, and serosal involvement in multivariate analyses. Conclusion For node-negative gastric cancer patients, tumor size, poor differentiation and serosal involvement are important markers to evaluate pregnosis.