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肠道通透性测定及其临床意义 被引量：3

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摘要 胃肠道是具有重要的免疫、内分泌和屏障功能的脏器。肠屏障的生物学研究已进行了近40年．随着研究的深入．人们对肠屏障衰竭的病理生理过程及其后果都有了较清楚的了解。肠屏障功能包括肠道黏膜的完整、正常肠道通透性、内脏血流、胃肠道激素的刺激、免疫功能、蠕动、黏液、泌酸及胃肠道正常菌群等．其中肠黏膜的完整性和通透性是最常用来代表肠屏障功能改变的两个因素。正常情况下，
作者 何桂珍
机构地区 北京协和医院肠内肠外营养科
出处 《中华胃肠外科杂志》 CAS 北大核心 2011年第3期226-228,共3页 Chinese Journal of Gastrointestinal Surgery
基金 北京市自然科学基金资助（7102127）
关键词 肠道通透性 临床意义 肠屏障功能 胃肠道正常菌群 胃肠道激素 测定 病理生理过程 免疫功能
分类号 R574 [医药卫生—消化系统]
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参考文献30

  • 1Han X. Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies. Recent Pat Inflamm Allergy Drug Discov, 2010,4(2):159-176.
  • 2Stoidis CN, Misiakos EP, Patapis P, et al. Spyropoulos BG. Potential benefits of pro- and prebiotics on intestinal mucosal immunity and intestinal barrier in short bowel syndrome. Nutr Res Rev, 2010,21 : 1-9.
  • 3Teshima CW, Meddings JB. The Measurement and Clinical Significance of Intestinal Permeability. Current Gastroenterology Reports, 2008,10(5) :443-449.
  • 4McOmber ME, Ou CN, Shulman RJ. Effects of timing, sex, and age on site-specific gastrointestinal permeability testing in children and adults. J Pediatr Gastroenterol Nutr, 2010,50 (3) :269-275.
  • 5Bjarnason I, Macpherson A, Hollander D. Intestinal permeability : an overview. Gastroenterology, 1995,108(5) : 1566-1581.
  • 6Watts T, Berti I, Sapone A, et al. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type 1 diabetes in BB diabetic-prone rats. Proc Natl Acad Sci, 2005, 102(8) : 2961-2921.
  • 7Sapone A, De Magistris L, upregulation is associated with subjects with type 1 diabetes 2006,55 (5) : 1443-1449. Pietzak M, et al. Zonulin increased gut permeability in and their relatives. Diabetes,.
  • 8Bosi E, Molteni L, Radaelli MG, et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia, 2006,49(12) :282-2827.
  • 9McGuekin MA, Eri R, Simms LA, et al. Intestinal barrier dysfunction in inflammatory bowel diseases. Inflamm Bowel Dis, 2009, 15( 1 ) : 100-113.
  • 10Miele E, Pascarella F, Quaglietta L, et al. Altered intestinal permeability is predictive of early relapse in children with steroid-responsive ulcerative colitis. Aliment Pharmaeol Ther, 2007,25 (8) :933-939.

二级参考文献19

  • 1黎君友,于燕,郝军,晋桦,许惠君.分光光度法测定血和小肠组织二胺氧化酶活性[J].氨基酸和生物资源,1996,18(4):28-30. 被引量：202
  • 2董良广,何桂珍,崔晓雨.肠源性多器官功能不全综合征机制的研究进展[J].中国临床营养杂志,2007,15(4):247-251. 被引量：3
  • 3Swank GM.Deitch EA.Role of the gut in multiple organ failure:bacterial translocation and permeability changes.World J Surg,1996,20:411.
  • 4Chiu CJ.McArdle AH,Brown R et al.Intestinal mucosal lesion in low-flow states.Arch Surg,1970,101:478.
  • 5Ciealese L,Lee K,Schraut W et al.Pyrurate prevents ischamia-reperfusion mucosal injury of rat small intestine.An J Surg,1996,1717:97.
  • 6Noguchi Y, James JH, Fischer JE, et al. Increased glutamine consumption in small intestine epithelial cells during sepsis in rats [J]. Am J Surg, 1997, 173(3) :199-205.
  • 7de Oliveira MA, Lemos DS, Diniz SO, et al. Prevention of bacterial translocation using glutamine : a new strategy of investigation [J]. Nutrition, 2006, 22(4) :419-424.
  • 8Siddiqui RA, Harvey KA, Zaloga GP, et al. Modulation of lipid rafts by to-3 fatty acids in inflammation and cancer: implications for use of lipids during nutrition support [ J ]. Nutr Clin Pract, 2007, 22(1) :74-88.
  • 9Babcock TA, Dekoj T, Espat NJ. Experimental studies defining omega-3 fatty acid antiinflammatory mechanisms and abrogation of tumor-related syndromes [ J ]. Nutr Clin Pract, 2005, 20(1) :62-74.
  • 10Calder PC. Polyunsaturated fatty acids and inflammation [ J ]. Prostaglandins Leukot Essent Fatty Acids, 2006, 75 ( 3 ) : 197-202.

共引文献46

同被引文献20

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二级引证文献17

中华胃肠外科杂志
2011年 第3期

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