期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血小板源性生长因子受体-α及其配体PDGF-A在人乳腺癌中表达的意义 被引量：4

Expression of platelet-derived growth factor receptor α and its ligand PDGF-A in breast cancer
下载PDF
导出
摘要 目的:探讨乳腺癌组织中血小板源性生长因子受体-α(PDGFR-α)与血小板源性生长因子-A(PDGF-A)表达,两者的表达相关性,及其在淋巴结转移中的作用。方法:以免疫组织化学方法检测PDGFR-α和PDGF-A的蛋白表达,分析PDGFR-α与淋巴结转移等临床病理参数间关系。结果:在所检测的样本中PDGFR-α和PDGF-A在乳腺癌组织中的阳性表达率分别为51.7%和61.7%,其表达与淋巴结转移具有一定的相关性(P<0.01)。同时PDGFR-α的表达与PDGF-A也具有一定的相关性。结论:PDGFR-α与PDGF-A能够在乳腺癌中高表达,可能有助于肿瘤细胞发生淋巴结转移。 AIM： To investigate the potential significance of platelet-derived growth factor receptor-α（PDGFR-α） and platelet-derived growth factor A（PDGF-A） expression in mammary carcinomas,and analyze its correlation with the lymph node metastasis and the expression of PDGF-A.METHODS： Used immunohistochemistry to detect the protein expression of PDGFR-α and PDGF-A in paraffinembedded breast carcinomas.RESULTS： The expression of PDGFR-α and PDGF-A were observed in 51.7% and 61.7% in the breast carcinomas,respectively and showed an association with lymph node metastasis（P〈0.05）.A correlation was also found with the expression of PDGFR-αand PDGF-A（P〈0.05）.CONCLUSION： PDGFR-α is expressed in invasive breast carcinomas and is associated with biological aggressiveness.
作者 刘得水 张晓杰 陈刚 卢长方 董海影
机构地区 齐齐哈尔医学院微形态实验室 齐齐哈尔医学院教务处 齐齐哈尔医学院科技处 齐齐哈尔医学院病理教研室
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2011年第3期313-314,316,共3页 Chinese Journal of Cellular and Molecular Immunology
关键词 乳腺肿瘤 血小板源性生长因子受体-α 血小板源性生长因子-A(PDGF-A) 淋巴结转移 breast cancer platelet-derived growth factor receptor α（PDGFR-α） platelet-derived growth factor A（PDGF-A） lymph node metastasis
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献9

  • 1Betsholtz C, Karlsson L. Developmental roles of platelet-derived growth factors[J]. Bioessays. 2001, 23(6) : 494 -507.
  • 2Apte SM, Bucana CD, Killion JJ, et al. Expression of platelet-derived growth factor and activated receptor in clinical specimens of epithelialovarian canner and ovarian carcinoma cell line[ J]. Gynecol Oncol, 2004, 93 ( 1 ) : 78 - 86.
  • 3Ostman A. PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma[ J]. Cytokine Growth Factor Rev, 2004, 15(4) : 275 -286.
  • 4Kim R, Emi M, Arihiro K, et al. Chemosensitization by STI571 targeting the platelet-derived growth factor/platelet-derived growth factor receptor-signaling pathway in the tumor progression and angiogenesis of gastric carcinoma[ J]. Cancer, 2005, 103 (9) : 1800 - 1809.
  • 5Oseini AM, Roberts LR. PDGFRalpha : a new therapeutic target in the treatment of hepatocellular carcinoma? [ J ]. Expert Opin Ther Targets, 2009, 13(4) : 443 -454.
  • 6Miguita L, Martinez EF, de Araújo NS, de Araújo VC. FGF-2, TGF- beta-l, PDGF-A and respective receptors expression in pleomorphic adenoma myoepithelial cells: an in vivo and in vitro study[J]. J Appl Oral Sci, 2010, 18(1) : 83 -91.
  • 7Petit A, Castillo M, Gaspa A, et al. Expression and mutational analyses of KIT and PDGFR-alpha in sarcomatoid renal cell carcinoma [J]. Histopathology, 2009, 55(2): 230-232.
  • 8Hunter SB, Brat DJ, Olson JJ, et al. Alterations in molecular pathways of diffusely infiltrating glial neoplasms: application to tumor classification and antitumar therapy [ J ]. Int J Oncol, 2003,23 (4) : 857 - 869.
  • 9De Jong JS, Van Diest PJ, Der Valk PV, et al. Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: an inventory in search of autocrine and paracrine loops[J]. J Pathol, 1998, 184(1) : 44-52.

同被引文献26

  • 1袁向飞(综述),陆敏(审校).Ras/MAPK与PI3K/Akt信号转导通路及其相互作用[J].国际检验医学杂志,2006,27(3):261-263. 被引量：22
  • 2李威,王培忠.乳腺癌患者生存质量的测量量表及其研究进展[J].中国肿瘤临床,2006,33(19):1132-1135. 被引量：35
  • 3Tavassoli F A,Devileep P.World Health Organization of tumors,pathology and genetics,tumors of breast and female genital[M].Iyon:IARC Press,2003:10.
  • 4Betsholtz C,Lindblom P,Bjarnegard M,et al.Role of Platelet2 derived growth factor in mesangium develoPment and vasculoPa2 thies:lessons from Platelet2 derived growth factor and Platelet2de2 rived growth factor receP tormutations in mice[J].CurrOP in NePhrol HyPertens,2004,13 (1):45-52.
  • 5Dancey J, Sausville EA. Issues and progress with protein kinaseinhibitors for cancer treatment. Nat Rev Drug Discover, 2003,2 ;293-313.
  • 6Nalwoga H, Ames JB,Wabinga H,et al. Expression of EGFR andc-kit is associated with the basal-like phenotype in breast carci-nomas of African women. APMIS,2008,116(6) :515-525.
  • 7Vranic S,Frkovic-Grazio S,Lamovec J,et al. Adenoid cystic car-cinomas of the breast have low Topo H a expression but fre-quently overexpress EGFR protein without EGFR gene amplifi-cation. HumanPathol,2010,41(11) : 1617-1623.
  • 8Cleator S, Heller W, Coombes RC. Triple-negative breast cancer :therapeutic options. Lancet Oncol ,2007,8(3) :235-244.
  • 9Valtola R,Salven P,Heikkila P,et al. VEGFR-3 and its ligandVEGF-C are associated with angiogenesis in breast cancer. AmPathol, 1999,154(5) :1381-1390.
  • 10Carvalho L,Milanezi E,Matin A,et al. Over exprssion of platele-derived growth factor receptor a in breast cancer is assosiatedwith tumor progression. Breast Cancer Res,2005,7:788-795.

引证文献4

二级引证文献34

细胞与分子免疫学杂志
2011年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部