围生期孕妇血清IL-6、TNF-α及外周血T淋巴细胞亚群变化的研究

The study on the changes of serum IL-6,TNF-α and peripheral blood T lymphocyte subsets in the pregnant women during perinatal period

目的:探讨围生期孕妇血清IL-6、TNF-α及外周血T淋巴细胞亚群变化规律。方法:选取本院100例产妇为研究对象,将其分别于分娩发动前、妊娠发动时及分娩后1、3 d的血清IL-6、TNF-α及外周血T淋巴细胞亚群水平进行统计及比较。结果:经研究发现,妊娠发动时血清IL-6、TNF-α高于分娩前及分娩后1、3 d,CD3+、CD4+、CD8+及CD4/CD8水平均呈现先降后升的趋势,经比较,P均<0.05,均有显著性差异。结论:围生期孕妇血清IL-6、TNF-α及外周血T淋巴细胞亚群水平呈现一定的变化规律,值得进一步研究探讨。

AIM： To study the change law of serum IL-6,TNF-α and peripheral blood T lymphocyte subsets in the pregnant women during perinatal period.METHODS： 100 pregnant women in our hospital from November 2009 to October 2010 were selected as research object,and the serum IL-6,TNF-α and peripheral blood T lymphocyte subsets before and at labor onset occurring,after delivery at the first and third day were analyzed and compared.RESULTS： According the study,the serum IL-6 and TNF-αat labor onset occurring were higher than those before labor onset and after delivery at the first and third day,the CD3＋,CD4＋,CD8＋ and CD4/CD8 decreased first and then increased,all P0.05,there were significant differences.CONCLUSION： The changes of serum IL-6,TNF-α and peripheral blood T lymphocyte subsets in the pregnant women during perinatal period has a regular pattern,and it is worthy of