S100B蛋白与颅脑损伤研究的新进展

New research progress of S100B protein and traumatic brain injury

颅脑损伤已成为严重的公共卫生问题,需不断努力提高救治水平。及时发现、诊断和治疗颅脑损伤很大程度上决定着患者的预后,所以寻找具有较高敏感性和特异性的颅脑损伤生化标记物有着极其重要的临床价值。目前,研究最多、最具潜力的标记物是S100B蛋白,本文就其结构、功能及其对颅脑损伤严重程度及预后的应用研究进展的问题进行综述。

Traumatic brain injury has become a serious public health problem.Timely detection,diagnosis and treatment of brain injury are closely related with the prognosis of patients,so looking for high sensitivity and specificity of biochemical markers of brain injury has important clinical value.Currently,the most studied and most promising marker is the S100B protein.In this article,the author reviews the structure and function of S100B,and its significance on the severity of brain injury and prognosis.