应用ROC曲线评价神经元特异性烯醇化酶对肺癌诊断的意义

Evaluation of the significance of NSE in diagnosis of lung cancer by ROC curve analysis

目的:应用受试者工作特征曲线(Receiver operating characteristic,ROC)曲线分析评价肿瘤标志物神经元特异性烯醇化酶(Neuron-specific enolase,NSE)对肺癌的诊断价值。方法:利用回顾性分析方法,分析了123例肺癌患者及109例肺部良性疾病患者的血清NSE水平,采用ROC评价NSE对肺癌的诊断效能。结果:①不同病理分型的肺癌患者组血清NSE水平均明显高于肺部良性疾病患者组(P<0.01);②通过ROC曲线分析,NSE对肺癌诊断的敏感度、特异度、曲线下面积分别为64.2%6、7.9%、0.73%;③NSE与CEA、CYFRA21-1联合检测分析对肺癌的诊断敏感度可达93.5%。结论:NSE单一指标检测对肺癌辅助诊断有一定的价值,其与CEA、CYFRA21-1联合检测可增加对肺癌诊断的敏感性。

Objective：To evaluate the significance of neuron-specific enolase（NSE）in diagnosis of lung cancer by ROC curve analysis.Methods：The NSE levels in serum of 123 lung cancer patients and 109 patients with benign lung diseases were analyzed retrospectively and the diagnostic performance of NSE in lung cancer was evaluated with Receiver operating characteristic curve（ROC）.Results：① Serum levels of NSE in the three pathological types of lung cancer patients were significantly higher than those in benign lung disease group（P0.01）;② The sensitivity,specificity,and area under ROC curve of serum NSE levels in lung cancer patients were respectively 64.2%,67.9% and 0.73%,by ROC curve analysis;③Combined determination of NSE,CEA and CYFRA21-1 had sensitivity of 93.5% for lung cancer diagnosis.Conclusion：The determination of NSE for diagnosis of lung cancer is of value,and the combined determination of NSE,CEA and CYFRA21-1 can increase sensitivity in diagnosis of lung cancer.