87例直肠腺癌患者肿瘤分期和细胞免疫状态分析

Correlation between the Stage of Rectal Adenocarcinoma and the Cell Immune Status

目的检测不同分期可手术根治直肠腺癌患者肿瘤分期和外周血T淋巴细胞亚群的变化.方法采用流式细胞仪,对87例手术前直肠腺癌组和40例对照组CD3、CD4、CD8、CD4/CD8、NK、B细胞进行检测.结果手术前直肠腺癌组CD8、NK细胞表达明显高于正常对照组(P<0.05);直肠腺癌患者Dukes A、B、C各期及T、N各分期间CD3、CD4、CD8、CD4/CD8、NK、B细胞比较无显著性差异(P>0.05).结论直肠腺癌患者存在细胞免疫功能失衡;但与肿瘤分期不明显.

Objective To study the relationship between periphery blood T lymphocytes subgroup and the stage of rectal adenocarcinoma in patients who could be cured surgically.Method CD3,CD4,CD8,CD4/CD8,natural killer（NK） cells and B cells of 87 patients with preoperative rectal adenocarcinoma and 40 controls were tested by flow ctyometry.Results The expression of CD8 and NK cell of patients in preoperative rectal adenocarcinoma group was significantly higher than those in the control group（P0.05）;the expression of CD3,CD4,CD8,CD4/CD8,NK and B cells had no significant differences among Duke’s A,B and C stage,different T stage and N status（P0.05）.Conclusion The rectal adenocarcinoma patients have an unbalanced function of cytoimmunity;and the status of cytoimmunity of rectal adenocarcinoma patients who could be cured surgically has no significant correlation with tumor stage.