中晚期非小细胞肺癌的支气管动脉介入治疗的临床研究

Clinical study of advanced lung cancer treated by bronchial arterial infusion

目的观察健择、顺铂联合支气管动脉介入化疗治疗中晚期非小细胞肺癌的临床疗效。方法将64例中晚期肺癌患者随机分为支气管动脉灌注治疗组(治疗组)和静脉注射治疗组(对照组),每组32例。观察两组疗效、生存率和生活质量。结果治疗组缓解率65.63%,中位生存期10个月,生存1年以上患者占52.13%;对照组缓解率28.13%,中位生存期6个月,生存1年以上患者占28.13%。治疗组的缓解率、1年生存率较对照组明显提高,差异均有统计学意义(P<0.05)。治疗组的恶心呕吐症状较对照组明显减少(P<0.05)。结论支气管动脉灌注治疗肺癌的临床疗效优于静脉滴注。更有利于改善患者的生活质量、延长患者生存时间的作用,减轻化疗药物的毒副作用。

Objective To evaluate the effect of bronchial arterial infusion in patients with advanced lung cancer.Methods A total of 64 patients with advanced lung cancer were randomized into two groups：32 cases were treated with bronchial arterial infusion therapy（treatment group） and 32 cases received vein infusion therapy（control group）.The clinical effects,survival rate and life quality were evaluated.Results The remission rate in the treatment group was 65.63%,and the median survival period was 10 months.The percentage of patients with a survival period of more than 1 year was 52.13%.The remission rate in the control group was 28.13% and the median survival period was 6 months.The percentage of patients with a survival period of more than 1 year was 28.13%.The rate of nausea and vomiting in the treatment group was significantly decreased（P0.05）.Conclusion The clinical effect of bronchial arterial infusion with DDP and Gem is superior to the vein infusion therapy.Bronchial arterial infusion therapy is effective in stabilizing the tumor foci.This method can not only improve the life quality and prolong the life span,but also lighten the side effect of chemotherapeutics.