广州市居民恶性肿瘤疾病负担研究

Research on disease burden of malignant neoplasm in Guangzhou citizen

目的综合分析恶性肿瘤疾病负担,为确定疾病防治重点,合理配置卫生资源提供依据。方法利用广州市2008年恶性肿瘤死亡资料,统计分析恶性肿瘤死亡率和伤残调整寿命年(DALY)等,评价恶性肿瘤疾病负担。结果广州市恶性肿瘤标化死亡率为116.74/10万,恶性肿瘤每千人造成的DALYs损失为17.77,男女性分别为22.16和13.22;早死所致寿命损失年(YLLs)和残疾所致寿命损失年(YLDs)分别占DALYs的84.40%和15.60%;每千人DALYs随年龄增加而上升,70～79岁组最高。恶性肿瘤疾病负担前3位为气管、支气管和肺,肝脏,鼻咽,DALYs/千人分别是4.62、3.25和0.99,男性排位基本与之一致,女性前3位为气管、支气管和肺,乳房,肝脏。结论广州市居民气管、支气管、肺,肝胆,鼻咽,乳房恶性肿瘤疾病负担较重。应加强早诊早治,采取有效的干预措施,降低广州市恶性肿瘤的疾病负担。

Objective To find out the key point for disease control and provide the basis for rational allocation of health resources by evaluating the burden of the malignant neoplasm patients in Guangzhou.Methods Malignant neoplasm mortality,disability-adjusted life year（DALY）,premature death caused by years of life lost（YLL） and years of life lost due to disability（YLD） are analyzed to evaluate the burden of malignant neoplasm patients,based on the death of malignant neoplasm information of Guangzhou in 2008.Results The standardized mortality rate of malignant neoplasm of Guangzhou was 116.74 per 100 000.All malignant neoplasm were responsible for 17.77 DALYs for every thousand population（for men and 13.22 for women）.In all DALYs,YLL s accounted for 84.40%,and YLDs 15.60%;DALY for each thousand people are gradually increased with age,the highest for the group of 70 to 79.The top 3 DALYs for every thousand population were trachea,bronchus and lung,liver and nasopharynx（4.62,3.25 and 0.99,respectively）,with the same rank in men,while female are trachea,bronchus and lung,breast and liver.Conclusion Trachea,bronchus,lung,liver and gallbladder,nasopharynx and breast cancer show heavier disease burden in Guangzhou.The burden of malignant neoplasm can be reduced if early diagnosis would be enhanced and more effective interventions would be adopted.