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以Ig/TCR基因重排为分子标志的儿童急性淋巴细胞性白血病微小残留病检测的技术方案 被引量：6

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摘要 微小残留病（minimal residual disease,MRD）是儿童急性淋巴细胞性白血病（acute lymphoblastic leukemia,ALL）的重要预后指标.目前普遍认为,MRD检测在评价治疗效果、判断预后及实施个体化治疗中具有重要的指导意义[1-2].如果诱导缓解治疗结束时MRD呈阴性,则患儿预后极佳,已有研究探讨降低化疗强度的可能性;而此时甚至到巩固治疗时MRD水平仍较高的患儿,则预后较差,需要更为强烈的化疗,甚至造血干细胞移植.
作者 李志刚 崔蕾 高超 李伟京 邢艳平 赵晓曦 廖紫婷 梁廷勳 吴敏媛
机构地区 首都医科大学附属北京儿童医院血液病中心 香港中文大学威尔斯亲王医院儿科学系
出处 《中华儿科杂志》 CAS CSCD 北大核心 2011年第3期165-169,共5页 Chinese Journal of Pediatrics
关键词 白血病微小残留病检测 急性淋巴细胞性白血病 TCR基因重排 分子标志 儿童 造血干细胞移植 Ig 预后指标
分类号 R733.71 [医药卫生—肿瘤]
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参考文献12

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二级参考文献24

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共引文献7

同被引文献74

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引证文献6

二级引证文献112

中华儿科杂志
2011年 第3期

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