彩色多普勒超声评价乳腺癌新辅助化疗疗效的研究

Study of Color Doppler Ultrasonography in evaluating effcet of neoadjuvant chemotherapy to breast carcinoma

目的:分析与新辅助化疗疗效相关的乳腺癌癌肿的声像图指标变化,与病理学检查结果进行比较,探讨彩色多普勒超声在乳腺癌新辅助化疗疗效评价上的应用价值。方法:利用彩色多普勒超声对接受新辅助化疗的43例乳腺癌患者的乳腺癌病灶变化进行观察,应用RECIST标准对乳腺癌新辅助化疗疗效进行评价,总结与新辅助化疗疗效相关的声像图指标。结果:本组43个病例通过临床触诊对新辅助化疗疗效进行评价,与病理学疗效评价符合率34.89%,敏感度59.09%;彩色多普勒超声检查评价乳腺癌病灶变化与病理学评价的符合率72.09%,敏感度86.36%,在病理判定有效组,新辅助化疗前后病灶内血流分级类型及RI值变化均具有显著性差异(P<0.05)。在病理判定无变化组,新辅助化疗前后病灶内血流分级类型及RI值变化均不具有显著性差异(P>0.05)。结论:彩色多普勒超声检查结合乳腺癌病灶的二维图像及血流信息,能对乳腺癌新辅助化疗后的疗效做出客观评价,具有一定的临床应用价值。

Objective：To study the relation of sonographical characters with the effect of neoadjuvant chemotherapy for breast cancer.Methods：All 43 patients with breast carcinoma were given CEF（CTX＋EPI＋5-FU）.All the lesions were undergone CDFI.Results：According to the clinical palpation,the accuracy,sensitivity for palpation in evaluating effect of neoadjuvant chemotherapy were 34.89%,59.09%.According to the length of breast carcinoma lesion,the accuracy,sensitivity for US in evaluating effect of neoadjuvant chemotherapy were 72.09%,86.36%.In partial remission group,there were significant differences in the blood mode and RI value of the breast tumors between before and after chemotherapy（P0.05）.In unchanged group,there was no difference in the blood mode and RI value of the breast tumors between before and after chemotherapy（P0.05）.Conclusion：It was useful to appraise the effect of neoadjuvant chemotherapy to breast carcinoma by Color Doppler Ultrasonography.