微波凝固术后肝癌患者免疫功能变化的初步研究

Immune function of patient with primary hepatocellular carcinoma after treatment of percutaneous microwave coagulation therapy

目的:检测微波凝固术后肝细胞肝癌患者外周血免疫细胞指标,探讨微波凝固治疗对患者机体免疫功能的影响。方法:68例行肝癌微波凝固术治疗的患者,分别于微波凝固治疗前1天、治疗后7天、14天、21天和28天时,应用流式细胞技术检查患者外周血CD4+、CD8+、CD3+、CD4+/CD8+比值、NK细胞水平的变化。结果:微波凝固后第1周,各指标较术前无明显变化,第2周开始,CD4+值比术前明显上升,CD8+明显下降,第4周开始NK细胞水平明显升高。结论:微波凝固治疗后肝癌患者免疫功能增强,将对肝癌患者的预后起到重要作用。

Objective：To study the influence of percutaneous microwave coagulation therapy（PMCT） on immunity function of patient with hepatocellular carcinoma（HCC）.Methods： Sixty eight HCC patients were treated by PMCT,the changes of CD4＋,CD8＋,CD4＋/CD8＋,NK cell by cytomatric analysis of peripheral blood were observed at day 1 before PMCT,daym 7 day 14,day 21 and 28 after PMCT.Results： At day 7,CD4＋,CD8＋,CD4＋/CD8＋,NK cell did not changed;CD4＋ increased obviously at day 14 after PMCT,while CD8＋ decreased obviously.NK cell level was increased at week 4 after PMCT.Conclusion： The immune function of patient was significantly improved in short-term after PMCT.And it played important role to prognosis of patient with liver cancer.