摘要
目的:研究我国湖北汉族人群TNF的基因多态性与非霍奇金淋巴瘤(NHL)发病的关系。方法:采用病例对照研究和聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测160例NHL患者和214例健康对照者中TNFα-308、LTα-252基因型分布。结果:NHL组与健康对照组TNFα-308基因型、等位基因频率总体分布差异无统计学意义(P均>0.05);NHL组与健康对照组相比LTα-252 AA基因型频率相比明显减低,差异有统计学意义(19%比29%,χ2=4.513,P=0.034,OR=1.697,95%CI:1.039-2.773),而LTα-252 GG、AG基因型及等位基因频率总体分布差异无统计学意义(P均>0.05);TNFα-308、LTα-252基因型与NHL患者的病理类型、临床分期及进展无明显相关性(P均>0.05)。结论:LTα-252位点基因型与湖北汉族人群NHL发病有相关性。
Objective:To study the distribution of TNF gene polymorphisms in patients with non-Hodgkin′s lymphoma(NHL) in Hubei province with Han nationality.Methods: Total of 160 patients with NHL and 214 healthy controls were genotyped by the PCR-RFLP method for TNFα-308,LTα-252 polymorphisms.Results: There wasn't significant difference of TNFα-308 gene polymorphism in NHL group and health control group(P0.05).There was significant difference of LTα-252 AA genotype between NHL group and healthy control group,the frequency of LTα-252 AA genotype of NHL patients was significantly lower than that in control group(P0.05).There were no associations between TNFα-308,LTα-252 gene polymorphisms and pathotype,clinical stages and disease progression in NHL patients.Conclusion: LTα-252 genotype was associated with NHL in Hubei province with Han nationality.
出处
《现代肿瘤医学》
CAS
2011年第3期540-543,共4页
Journal of Modern Oncology