摘要
(R)-乙基-2-吡啶亚砜与(4R,5R)-二(羟基-二苯基-甲基)-2,2-二甲基-1,3-二氧戊环(TAD-DOL)可以形成物质的量比为1∶1的手性包结晶体,X射线衍射分析确定该晶体属单钭晶系,P21空间群,a=0.9701(2)nm,b=0.9953(2)nm,c=1.7392(2)nm;β=92.079°(14),V=1.6781(5)nm3,Z=2,Dc=1.230g/cm3,分子式C38H39NO5S,Mr=621.76,最终偏离因子R=0.0351,RW2=0.0772,Flack值为0.1(2).结构分析表明,主客体存在分子间氢键.光学纯的TADDOL与消旋的乙基吡啶亚砜(1)作用时,TADDOL对1具有很好的手性识别能力,选择性地与1的一个对映体形成氢键,长成晶体.
The synthesis and crystal structure of 1∶1 inclusion chiral crystal formed from ( R ) ethyl 2 pyridyl sulfoxide with ( 4R,5R ) α,α,α,α tetraaryl 1,3 dioxolane 4,5 dimethanol(TADDOL) were reported here. The crystal belongs to monoclinic, space group P2 1, a= 0.970 1(2) nm, b = 0.995 3(2) nm, c = 1.739 2(2) nm; β= 92.079° (14), V= 1.678 1(5) nm 3, M r= 621.76 , Z =2, D c= 1.230 g/cm 3. The final refinement converges to R = 0.053 1 and R w 2 = 0.077 2 for 2 335 observed independent reflections. Flack value is 0.1 (2). There is an intermolecular hydrogen bond in the inclusion crystal. Chiral TADDOL and ethyl 2 pyridyl sulfoxide(1) can be recognized each other in the inclusion crystal. Moreover, sulfoxide(1) in high enantiomeric excess was preparaed by resolution through inclusion complexation with the chiral TADDOL. The absolute configuration of (-) ethyl 2 pyridyl sulfoxide was confirmed to be ( R ), which was assigned by the ( R,R ) absolute configuration of the TADDOL as an internal reference.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1999年第7期1081-1084,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金