卟啉与吩噻嗪分子间和分子内的光致相互作用

Photoinduced Intermolecular and Intramolecular Actions Between Phenothiazine and Porphyrin

光动力疗法（ＰＤＴ）药物研究的一个重要分支是合成新的含卟啉结构的化合物，以获得较好的癌组织细胞定位能力和较强的组织穿透能力［１］．Ｍｅｈｔａ等［２，３］发现卟啉和一些具有细胞内识别能力的抗癌分子组成的二元化合物表现出较强的光诱导核酸酶活性，同时不改变...

A dyad of phenothiazine and porphyrin and their reference model compounds were synthesized. The intermolecular and intramolecular photoinduced singlet energy transfer and electron transfer were studied. The results indicated that the intermolecular ground state action between PorBu and PTZBu is negligible, the excited PTZBu partly transfer its singlet energy to PorBu. Exciting PorBu, the intermolecular electron transfer occurs with a rate 1 11×10 10 s -1 \5mol -1 \5L. For exciting PTZ moiety in dyad, due to PTZ′s lower Φ and smaller ε , it could not transfer its singlet energy to porphyrin. Exciting the porphyrin moiety could induce electron transfer from phenothiazine moiety to porphyrin moiety.