白疕软膏对豚鼠银屑病样模型影响的研究

Effect of Baibi Ointment to Psoriasis Guinea Pig Model

目的:探讨白疕软膏治疗银屑病的药效及作用机理。方法:采用5%心得安乳剂建立豚鼠银屑病样模型,观察白疕软膏对豚鼠银屑病样模型组织病理改变的影响;采用放射免疫法检测豚鼠银屑病样模型皮损中细胞因子IL-2、IL-6、IL-8的水平,观察白疕软膏对豚鼠银屑病样模型皮损中细胞因子的影响。结果:白疕软膏对豚鼠银屑病样模型组织病理改变有治疗作用。结论:白疕软膏对豚鼠银屑病样模型的治疗作用机理可能是通过对角质形成细胞增殖的抑制及对细胞因子的调节而发挥作用。白疕软膏是治疗银屑病的有效外用制剂,值得进一步研究和推广。

Objective：The aim of this study is to investigate the effects and mechanisms of Baibi ointment for treating Psoriasis.Methods：5% propranolol emulsion was applied externally on the back of a guinea pig＇s ear to produce the poriasis-like dermatitis model to observe the effects of Baibi ointment on the histopathological changes of the model.Radioimmunoassay was used to observe the levels of cytokines like IL-2、IL-6 and IL-8,and the effects of the ointment to the cytokines.Results：Baibi ointment has therapeutical effects on the histopathological changes of the models of poriasis-like dermatitis in guinea pigs.The mechanism is probably by inhibiting the multiplication of the Malpighian cell and regulating the cytokines.Thus,Baibi ointment is an effective external preparation to treat psoriasis,and is worthy of deeper reasearch and generalization.