脐血叶酸水平与新生儿出生体重和肺透明膜病的关系

Relationship between folic acid levels of cord blood and birth weight, hyaline membrane disease in newborns

目的探讨脐血叶酸水平与新生儿出生体重和肺透明膜病的关系。方法将87例新生儿按照胎龄、出生体重、临床表现及胸部X线检查分别分为早产儿组（42例）和足月儿组（45例）、胎儿宫内发育迟缓组（28例）和正常妊娠对照组（59例）、早产儿肺透明膜病组（13例）和早产儿对照组（15例），测定各组新生儿脐血叶酸水平。结果早产儿组脐血叶酸水平低于足月儿组[（10．87±4．31）nmol／L比（13．56±5．07）nmol／L，P〈0．05]；胎儿宫内发育迟缓组脐血叶酸水平低于正常妊娠对照组[（11．01±4．29）nmol／L比（14．87±5．14）nmol／L，P〈0．05]；早产儿肺透明膜病组脐血叶酸水平低于早产儿对照组[（9．15±4．02）nmol]L比（12．91±4．51）nmol/L，P〈0．05]；脐血叶酸水平与新生儿出生体重呈正相关（r=0．1825）。结论脐血叶酸水平与早产、胎儿宫内发育迟缓和新生儿肺透明膜病的发生有关。

Objective To explore the relationship between folic acid levels of cord blood and birth weight, hyaline membrane disease in newborns. Methods Eighty-seven newborns were divided into premature infant group （42 cases ） and term infant group（45 cases ）, intrauterine growth retardation group （28 cases ） and control group （59 cases ）, hyaline membrane disease of premature infant group （ 13 cases ） and premature infant control group（ 15 cases） according to the gestational age, birth weight, clinical manifestation and chest X-ray, respectively. Folic acid levels of cord blood were measured. Results The folic acid level of cord blood in premature infant group was lower than that in term infant group [（10.87±4.31） nmol/L vs. （ 13.56 ± 5.07 ） nmol/L,P 〈 0.05 ]. The folic acid level of cord blood in intrauterine growth retardation group was lower than that in control group [ （ 11.01 ± 4.29） nmol/L vs.（ 14.87 ± 5.14） nmol/L,P 〈 0.05 ]. The folic acid level of cord blood in hyaline membrane disease of premature infant group was lower than that in premature infant control group [ （9.15 ± 4.02） nmol/L vs. （12.91 ± 4.51 ） nmol/L,P 〈 0.05]. The positively correlation was found between the folic acid level of cord blood and birth weight in newborns （r = 0.1825）. Conclusion The folic acid level of cord blood is correlated with the occurrence of premature infants, intrauterine growth retardation and hyaline membrane disease in newborns.