摘要
目的:检测卵巢上皮性肿瘤患者血清中干扰素诱导蛋白-10(IP-10)的含量,并结合临床病理特征分析IP-10在卵巢上皮性肿瘤侵袭转移过程中的作用。方法:采用ELISA法检测20例正常对照、20例卵巢良性上皮性肿瘤患者、48例卵巢上皮性癌患者血清中IP-10的含量,并对其与手术病理分期、组织学分级、组织学类型进行分析。结果:IP-10在卵巢上皮性癌患者血清中含量均显著低于卵巢良性上皮性肿瘤患者及正常对照组(P<0.01),且IP-IO在卵巢上皮性癌患者血清中的含量与手术病理分期(P<0.05)、组织学分级相关(P<0.05),而与组织学类型无相关性(P>0.05)。结论:卵巢上皮性癌患者血清中p-10含量与手术病理分期、组织学分级有关,并与卵巢上皮癌的侵袭、转移、疾病进展有关。
Objective： To study the expression and significance of IP-10（IFN-T-mducible Protein-10） in ovarian epithelial cancer.Methods： The concentrations of IFN-γ-mducible Protem-10 in blood serum were detected by means of ELISA respectively m 20 cases of patients with ovarian epithelial benign tumors and 48 cases of ovarian epithelial tumors,and 20 cases of healthy persons serve as the control.Results： The serum levels of IP-10 in patients with ovarian epithelial cancer（3.516pg/ml±1.349pg/ml） were lower than in patients with epithelial benign tumor（63.723 pg/ml±9.692 pg/ml） and normal people（70.077 pg/ml±11.034 pg/ml,P0.01）.The serum levels of IP-10 in patients with ovarian epithelial cancer correlated with their clinical stage（P0.05） and histology grade（P0.05）.The serum levels of IP-10 in patients with ovarian epithelial cancer did not correlated with pathologic typing（P0.05）.Conclusion： IP-10 were lower expressed in ovarian epithelial cancer,and they have correlation with invasion and metastasis,and they have some correlation with clinical pathology and prognosis of epithelial ovarian cancer.
出处
《中国伤残医学》
2011年第3期23-24,共2页
Chinese Journal of Trauma and Disability Medicine
