期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肿瘤转移抑制基因与卵巢癌 被引量：3

下载PDF
导出
摘要 卵巢癌严重威胁妇女生命健康，死亡率居妇科恶性肿瘤首位．五年生存率仅30％左右。浸润与转移，作为恶性肿瘤的本质特征．也是卵巢癌发生发展的最大特点，严重影响卵巢癌患者的疗效及预后。而恶性肿瘤的浸润、转移如同肿瘤的发生，涉及很多基因的变化和作用，
作者 周冬梅 生秀杰
机构地区 广州医学院第三附属医院妇产科
出处 《实用医学杂志》 CAS 北大核心 2011年第7期1306-1308,共3页 The Journal of Practical Medicine
基金 广东省科技厅项目(编号:2009B060700080)
关键词 肿瘤转移抑制基因 卵巢癌患者 妇科恶性肿瘤 五年生存率 死亡率 多基因 浸润
分类号 R737.31 [医药卫生—肿瘤]
  • 相关文献

参考文献17

  • 1Lacombe M L, Milon L, Munier A, et al. The human Nm23/nucleoside diphosphate kinases [J]. J Bioenerg Biomembr, 2000,32 (3) : 247-258.
  • 2Desvignes T, Pontarotti P, Fauvel C, et al. Nme protein family evolutionaryhistory, a vertebrate perspective [ J ]. BMC Evolutionary Biology, 2009,9 : 256.
  • 3Mandai M, Konishi I, Koshiyama M, et al. Expression of metastasis-related Nm23-H1 and Nm23-H2 genes in ovarian carcinomas: correlation with clinicopathology, EFR, c-erbB-2, and e-erB-3 genes, and sex steroid receptor expression [J]. Cancer Res, 1994,54(7) : 1825-1830.
  • 4Tas F, Tuzlali S, Aydiner A, et al. Prognostic role of Nm23 gene expression in patients with ovarian cancer [J]. Am J Clin Oncol, 2002, 25(2) : 164-167.
  • 5Tomic S, Ilie Forko J, Babic D, et al. e-erbB-2, p53, and Nm23 proteins as prognostic factors in patients with epithelial ovarian carcinoma [J]. Croat Med J, 2003,44(4) :429-434.
  • 6甘西西,李小红,王崇宇,叶玲玲,李继承.卵巢上皮性肿瘤中nm23H1基因的突变及其与临床病理特征的关系[J].实用医学杂志,2007,23(19):3011-3013. 被引量：1
  • 7Li J, Zhou J, Chen G, et al. Inhibition of ovarian cancer metastasis by adeno-associated virus-mediated gene transfer of nm23H1 in an orthotopic implantation model [ J]. Cancer Gene Ther, 2006, 13(3) :266- 272.
  • 8Hua K, Din J, Cao Q, et al. Estrogen and progestin regulate HIF-1 alpha expression in ovarian cancer cell lines via the activation of Akt signaling transduction pathway [J]. Oncol Rep, 2009,21 (4) : 893-898.
  • 9Hua K, Feng W, Cao Q, et al. Estrogen and progestin regulate metastasis through the PI3K/AKT pathway in human ovarian cancer [J]. Int J Oncol, 2008,33(5) :959-967.
  • 10Youn B S, Kim D S, Kim J W, et al. NM23 as a prognostic biomarker in ovarian serous carcinoma [J]. Mod Pathol, 2008,21 ( 7 ) : 885-892.

二级参考文献26

  • 1杨月琴,李继承.卵巢上皮性癌nm23H1基因遗传不稳定性与临床病理特性的关系[J].癌症,2006,25(6):713-717. 被引量：6
  • 2[1]Seraj MJ, Samant RS, Verderame MF, et al. Funcfonal evi dence for a novel human breast carcinoma metastasis suppresor, BRMS1,encoded at chromosome 11q13[J] .Cancer Res, 2000,60:2764-2769
  • 3[2]Weitzel JN, Patel J, Smith DM, et al. Molecular genetic changes associated with ovarian cancer[ J ]. Gynecol Oncol, 1994,55:245-252
  • 4[3]Hu W, Mcrea PD, Deavers M, et al. Increased expression offascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tu mors[J]. Clin Exp Metastasis,2000,18:83-88
  • 5[4]Josephine CA,James DC, G eorgina DM, et al. Cell-matrix ad hesions differentially regulate fascin phosphorylation [ J ]. Mol Biol Cell, 1999,10:4177-4190
  • 6Young TN,Rodriguez GC,Rinehart AR,et al.Characterization of gelatinases linked to extracellular matrix invasion in ovarian adenocarcinoma:purification of matrix metalloproteinase 2 [ J].Gynecol Oncol,1996,62(1):89-99.
  • 7Yisimio S,Hoyhtya M and Turpeenniemi-Hujanen T.Serum matrixmetalloproteinases-2,-9 and tissue inhibitors of metalloproteinases-1,-2 in lung cancer-TIMP-1 as a prognostic marker[J].Anticancer Res,2000,20(2B):1311-1316.
  • 8Seraj MJ, Samant RS, Verderame MF, et al. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. Cancer Res, 2000, 60: 2764-2769.
  • 9Weitzel JN, Patel J, Smith DM, et al. Molecular genetic changes associated with ovarian cancer. Gynecol Oncol, 1994, 55 : 245- 252.
  • 10Trosko JE, Ruch RJ. Cell-cell communication and carcinogenesis. Front Biosci, 1998,3:208-236.

共引文献34

同被引文献57

  • 1钱和年.卵巢癌生物学治疗的展望[J].中华妇产科杂志,1994,29(7):386-388. 被引量：2
  • 2孙军,王贺玲,李岩.姜黄素对人肝癌细胞中血管内皮生长因子表达的影响[J].中华消化杂志,2006,26(12):843-844. 被引量：20
  • 3王玮 沈鸿敏 徐素欣 等.外周血与卵泡液中白介素1β在控制超排周期中的变化[A]..中华医学会第四届全国妇产科内分泌学术会议[C].浙江杭州,2001.8,24.
  • 4Oppenheim JJ,Kovacs EJ,Matsushima K,et al.There is more thanone interleukin-1[J].Immunol Ioday,1996,7(2):45.
  • 5Wilson AG,Symons JA,McDowell TL,et al.Eeffets of a polymor-phism in the human tumor necrosis factor alpha promoter on tran-scriptional actviation[J].Proc Natl Acad Sci USA,1997,94(7):3195-3199.
  • 6Turer DM,Willimas DM,Sankaran D,et al.An investigation ofpolymorphism in the interleukin-10 gene promoter[J].Eur J Im-munogenet,1997,24(1):1-8.
  • 7黄昀,金焰,赵育桢,等.人卵巢癌细胞UACC-1598单克隆亚系双微体数目稳定性研究[C].北方遗传资源的保护欲利用研讨会论文汇编,2010.
  • 8MANDRIOTA S J,JUSSILA L,JELTSCH M,et al.Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis[J].EMBO J,2001,20(4):672-682.
  • 9JORGENSEN T J,HELZLSOUER K J,CLIPP S C,et al.DNA repair gene variants associated with benign breast disease in high cancer risk women[J].Cancer Epidemiol Biomarkers Prev,2009,18:346-350.
  • 10SAHARINEN P,PETROVA T V.Molecular regulation of lymphangiogenesis[J].Ann N Y Acad Sci,2004,1014(3):762-771.

二级引证文献18

实用医学杂志
2011年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部