竹荪提取物体内抗氧化活性

The Antioxidant Activities in vivo of the Extract from Dictyophora indusiata Fruit Body

利用D-半乳糖制造衰老模型小鼠,研究竹荪提取物在衰老模型小鼠体内的抗氧化作用。结果表明:在低剂量,中剂量和高剂量(50、100、200mg/kg.d)3个剂量条件下,小鼠的体重增量与空白组相比不显著,说明竹荪提取物在实验剂量下没有明显的毒、副作用;中剂量和高剂量下,小鼠肝重、脾重与空白组差异均不显著,与模型组差异分别为显著和极显著,说明竹荪提取物可以有效保护受损内脏,防止氧化损伤;竹荪提取物可明显提高衰老模型小鼠血清中SOD酶活力,降低衰老模型小鼠血清中MDA含量,并且竹荪提取物与小鼠血清中SOD酶活力和MDA含量呈明显的剂量效应关系,说明竹荪提取物具有较强的体内抗氧化活性。

The antioxidant activity in vivo of the extract from Dictyophora indusiata fruit body was investigated,and the result showed that none of the low dose（50 mg/kg·d）,middle dose（100 mg/kg·d） and high dose（200 mg/kg·d） had significant influence on body weight increasement（p〉0.05）,which indicated that the extract of D.indusiata fruit body didn’t have poisonous or side effect to animal.In the respect of liver and spleen weight,middle dose and high dose reached the level of control,which indicated that the D.indusiata extract could protect impaired apparatus.The extract of D.indusiata fruit body could significantly increase SOD vitality and reduce MDA content of mice injected into D-galactose,and the dose and antioxidant activity had dose-response relationship.