认知和情绪冲突的监控与解决：来自轻度认知损伤的证据

Monitoring and Resolution of Cognitive and Emotional Conflict:Evidence from Mild Cognitive Impairment

轻度认知损伤(mild cognitive impairment,MCI)是介于正常老化和痴呆之间的过渡阶段。近年来,执行控制的损伤被认为是MCI的核心特征之一。当前,在MCI执行控制的领域内,对冲突监控与解决的特征及其神经机制的研究较少。本研究拟通过认知及情绪冲突实验范式,结合脑成像技术,探讨遗忘型MCI(amnestic MCI,aMCI)认知和情绪冲突的监控与解决的特征及相应的脑激活模式;通过对比aMCI和正常老年人在认知和情绪冲突任务中激活的神经环路,考察aMCI是否在执行加工的神经网络上存在激活异常。在上述研究基础上,研究者拟探讨aMCI在执行控制的冲突监控与解决上是否存在一般性的损伤机制,同时试图寻找aMCI在执行控制的冲突监控与解决方面的认知及神经生物学标记。这对深入理解痴呆的发病进程并有针对性的开展痴呆的早期识别与干预具有重要的理论意义和实践意义。

Mild cognitive impairment （MCI） is a transitional stage between normal aging and Alzheimer＇s disease （AD）.Recently,executive control deficits were considered as one of the core characteristics of MCI.At the present,we have little knowledge about the characteristics of conflict monitoring and resolution and the corresponding neural mechanisms of MCI.In the present proposal,we aim to explore whether persons with amnestic MCI （aMCI） would show impairments in the behavioral and neural mechanisms with cognitive and emotional conflict tasks.Meanwhile,through the comparison of neural circuit during processing cognitive and emotional conflict tasks between persons with aMCI and healthy controls,we intend to explore whether aMCI have deficits in neural circuit.Totally,we try to explore whether persons with aMCI have general deficits in conflict monitor and resolution of executive control,and we also try to find the cognitive and neurobiological markers of executive controls in aMCI.The present study will be helpful to understand the progression of AD,and also has important theoretical and practical implications for early identification and early intervention of MCI and AD.