期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

手术前后非小细胞肺癌血清ABCG2表达水平的变化及临床意义 被引量：3

Clinical significance of serum ABCG2 level in patients with non-small cell lung cancer before and after operation
下载PDF
导出
摘要 目的观察非小细胞肺癌患者手术前后血清中ABCG2蛋白表达水平的变化,并探讨其临床意义。方法用ELISA法对60例非小细胞肺癌患者手术前、后及15例健康成人血清中ABCG2表达水平进行检测。结果非小细胞肺癌患者治疗前血清ABCG2表达水平明显高于健康成人组(P<0.05),其术后血清ABCG2的水平亦明显低于术前(P<0.05),但与健康成人差异无统计学意义(P>0.05);患者治疗前血清ABCG2的水平与各种临床病理特征无关,而术后血清ABCG2水平与肺癌临床分期有关。结论 ABCG2有望作为判断非小细胞肺癌疗效及预后的有效指标。 ObjectiveTo observe the changes of serum ABCG2 level in patients with non-small cell lung cancer before and after operation,and then to explore its clinical significance.Methods Serum ABCG2 levels of 60 patients with non-small cell lung cancer before and after operation and 15 healthy adults were detected by ELISA.Results Serum ABCG2 level of patients with non-small cell lung cancer before operation was significantly higher than that of the healthy adults （P〈0.05）,while the serum ABCG2 level of these patients after operation was obviously lower than that of before operation （P〈0.05） but was not different from that of the healthy adults.The preoperative serum ABCG2 level was irrelevant to clinical features,while the postoperative serum ABCG2 level was related to stage of cancer.Conclusion Serum ABCG2 level might be used as an index to judge curative effect and prognosis of non-small cell lung cancer.
作者 王大星 谢彤
机构地区 广西医科大学研究生学院 广西医科大学附属肿瘤医院
出处 《中国癌症防治杂志》 CAS 2011年第1期56-58,共3页 CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
基金 广西自然科学基金资助项目(桂科青0728084)
关键词 ABCG2 非小细胞肺癌 手术 ABCG2 NSCLC Operation
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献12

  • 1Doyle LA, Yang W, Abruz,v.o LV, et al. A multidrug resistance transporter from human MCF27 breast cancer cells [J]. Proe Nail Aead Sei USA. 1998,22;9.5 (26) : 1566.5-15670.
  • 2Zhou S,Schuetz JD, Bunting KD,et al. The ABC transporter Bcrpl/ABCG2 is e- xpressed in a wide variety of stem celia and is a molecular determ inant ofthe side-population phenotype [J]. Nat Meal 2001,7(9) : 1028-1034,.
  • 3Maliepaard M,Scheffer GL,Faneyte IF,et al. Subcellular localization and distri- bution of the breast cancer resistance prtein la~msporter in normal human tissues [J]. Cancer Res,2001,61(8) : 3458-3464.
  • 4Doyle LA,Ross DD. Muhidrug resistance mediated by the breast cancer resist- ance protein BCRP(ABCG2) [J]. Oncogene,2003,22(47) : 7340-7358.
  • 5Istemino S, Mercier C, Bourasset F, et al. Expression, up-regulation, and trans- port activity of the multidrug-resistance protein Abcg2 at the mouse blod-brain bamerj [J]. Cancer Res,2004,64(9) : 3296-3301.
  • 6Fetsch PA, Abaft A, Litman T, et al. Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues [J]. Cancer Left,2006,235 (1) : 84-92.
  • 7Tamur AA ,Wakabayash IK,Onish IY,et nl. Re, eva luatlon and futactiona 1 ehm- 8ifieation of nonsynon~an ou* single nucleotide polym orphisms of the human ATP-binding eassette trarmpo~er ABCG2 [J]. Cancer Sei,2007,98(2) : 231- 239.
  • 8Furukawa T,Wakabayash IK,Tamura A,et al. Major SNP ( QI41K ) variant of human ABC transporter ABCG2 under goes lysosomal and proteasomal degra- dations [J]. Phann Res,2009,26(2) : 469-479.
  • 9Kondo T,Setoguchi T,Taga T. Persistence of a small suhpopulstion of cancer stem-like cells in the C6 glioma cell line [J]. Proc Natl Acad Sci USA,2004, 101 : 781-786.
  • 10tlo MM ,Ng AV ,Lam S,et al. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells [ J ]. Cancer Res ,2007,67 : 4827-4833.

二级参考文献9

  • 1MA Goodell,K Brose,G P aradis,et al.Isolation and function properties of murine hematipoietic stem cells that are replicating in vivo[J].J Exp Med,1996,183(4):1 797-1 896.
  • 2Kondo T,Setoguchi T,Taga T.Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line[J].Proc Natl Acad Sci USA,2004,101(3):781-786.
  • 3Chiba T,Kitak K,Zheng YW,et al.Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties[J].Hepatology,2006,44(1),240-251.
  • 4Sheng Zhou,John J Morris,Yuxiao Barnes,et al.Bcrp1 gene expression is required for normal numbers of side population stem cells in mice,and confers relative protection to mitoxantrone in hematopoietic cells in vivo[J].PNAS,2002,(99)19:12 339-12 344.
  • 5Doyle LA,Yang W,Abruzzo LV,et al.A multidrug resistance transporter from human MCF-7 breast cancer cells[J].Proc Natl Acad Sci USA,1998,95(26):15 665-15 670.
  • 6Hirshmann-Jax C,Foster AE,Wulf GG,et al.A distinct "side population" of cells with high drug efflux capacity in human tumor cells[J].PNAS,2004,101(39):14 228-14 233.
  • 7Jonker JW,Buitelaar M,Wagenaar E,et al.The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria[J].Proc Natl Acad Sci USA,2002,99(24):15 649-15 654.
  • 8Zhang W,Shannon W D,Duncan J,et al.Expression of drug pathway proteins is independent of tumor type[J].J Pathol,2006,209(2):213-219.
  • 9Yoh K,Ishii G,Yokose T,et al.Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer[J].Clin Cancer Res,2004,10(5):1 691-1 697.

同被引文献31

  • 1胡毅,冯奉仪,程书钧,高燕宁,肖汀,刘又宁.非小细胞肺癌患者血清中乳腺癌耐药蛋白的表达及与化疗疗效的关系[J].中华肿瘤杂志,2006,28(10):750-752. 被引量：5
  • 2牛海艳,申洪.ABCG2在肺癌中表达的定量研究[J].中国体视学与图像分析,2007,12(3):167-171. 被引量：11
  • 3Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Pro- spective identification of tumorigenic breast cancer cells [J]. Proc Natl Acad Sci U S A,2003,100(7) :3983-3988.
  • 4Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells[J]. Nature, 2004,432 (715) : 396-401.
  • 5Kondo T, Setoguchi T, Taga T. Persistence of a small subpopulation of cancer stem-like cellsin the C6 glioma cell line[J]. Proc Natl Acad Sci U S A, 2004,101(3) :781-786.
  • 6Dean M,Fojo T,Bates S. Tumour stem cells and drug re- sistance[J]. Nat Rev Cancer,2005,5(4) :275-284.
  • 7Robey RW, Polgar O, Deeken J, et al. ABCG2: determi- ning its relevance in clinical drug resistanee[J]. Cancer Metastasis Rev, 2007,26(1) : 39-57.
  • 8Apclti A,Orbhn TI, Varga N,et al. High level functional expression of the ABCG2 multidrug transporter in undif- ferentiated human embryonic stem cells[J]. Bioehim Bio- phys Acta,2008,1778(12) :2700-2709.
  • 9Polgar O,Robey RW, Bates SE. ABCG2: structure, func- tion and role in drug response [J]. Expert Opin Drug Metab Toxicol,2008,4(1) : 1-15.
  • 10Therasse P,Arbuek AG,Eisenhauer EA,et al. New guidelines to evaluate to the responds of treatment in solid tumer[J]. J Natl Cancer Inst,2000,92(3) :205-216.

引证文献3

二级引证文献2

中国癌症防治杂志
2011年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部