东北刺人参茎叶提取物对环磷酰胺致免疫抑制小鼠免疫功能的影响

Efftect of Extracts from Stems and Leaves of Oplopanax elatus on Immune Functions in Immuno-suppressed Mice Induced by Cyclophosphamide

目的:评价东北刺人参茎叶提取物对免疫抑制模型小鼠免疫功能的影响。方法:实验小鼠分为空白对照组、环磷酰胺(CTX)模型组、东北刺人参茎叶提取物高、中、低剂量组(按生药量计为5.2,2.6,1.3 g.kg-1),空白对照组与模型组给予等量生理盐水,连续给药7 d,观察东北刺人参茎叶提取物对实验动物免疫器官脏器指数、碳粒廓清能力、迟发型超敏反应(DTH)的影响。结果:与模型组比较,东北刺人参茎叶提取物各剂量组均能显著提高小鼠免疫脏器指数、单核巨噬细胞的吞噬功能及小鼠DTH(P<0.05～P<0.01)。结论:东北刺人参茎叶提取物有提高免疫抑制小鼠免疫功能的作用。

Objective：To evaluate the effects of the extracts from stems and leaves of Oplopanax elatus on the immune functions of immune-suppressed mice by cyclophosphamide.Method： Mice were randomly divided into 5 groups： control group,model group,low,moderate and high dose groups（1.3,2.6,5.2 g.kg-1） of the extracts from stems and leaves of O.elatus.The mice were examined for immune organ weight index,carbon particle clearance capability of macrophage,delayed type hypersensitivity.Result： Compared with model group,all dose groups could significantly increase the weight of the immune organs,carbon particle clearance capability of macrophage and delayed type hypersensitivity（P 0.05-P 0.01）.Conclusion： The extracts from stems and leaves of O.elatus can enhance the immune functions in immune-suppressed mice.