麻黄附子细辛汤和小青龙汤对过敏性鼻炎豚鼠作用的研究

Efficacy of Mahuang Fuzi Xixin Decoction and Xiaoqinglong Decoction on Allergic Rhinitis in Guinea Pigs

目的:比较麻黄附子细辛汤和小青龙汤对过敏性鼻炎(EAR)作用的差异。方法:采用卵清蛋白建立过敏性鼻炎豚鼠模型,随机分为4组:模型组、辛芩颗粒对照组(4.65 g.kg-1)、小青龙汤组(7.44 g.kg-1)、麻黄附子细辛汤(2.33 g.kg-1),另设正常对照组。3个药物治疗组每天ig给药1次,给药共14 d,以治疗前后的行为学体征积分、血液组胺和鼻黏膜切片病理变化为观测指标。结果:麻黄附子细辛汤组、小青龙汤组和辛芩颗粒组的治疗后体征积分和血液组胺含量均有降低,与正常组相比具有显著性差异(P<0.01)。麻黄附子细辛汤组的血液组胺含量(3.64±0.83)mg.L-1与小青龙汤组(4.58±0.51)mg.L-1和辛芩颗粒组(4.36±0.13)mg.L-1都有显著性差异(P<0.01),其对鼻黏膜炎症变化的修复略优于小青龙汤和辛芩颗粒。结论:麻黄附子细辛汤能改善过敏性鼻炎豚鼠症状,对血液组胺的降低和鼻黏膜的修复优于小青龙汤。

Objective： To compare the effective similarities and differences between the Xiaoqinglong decoction and Mahuang Fuzi Xixin decoction on experimental allergic rhinitis（EAR） in guinea pigs.Method： EAR was induced in guinea pigs with ovum albumin,and all the animals with EAR are randomly divided into 4 groups,i.e.EAR model group,the Xinqin granules control group treating with Xinqin granules 4.65 g.kg-1,treatment group with the Xiaoqinglong decoction 7.44 g.kg-1,and treatment group with the Mahuang Fuzi Xixin decoction 2.33 g.kg-1,supplemented with a normal group as the control.The experiment lasted 14 days.During the experimental period,attention was paid to observe changes in symptoms,histamine content in blood and morphological features of nasal mucosa under light microscopy.Result：The three treatment groups all reduced the accumulative scores of the symptoms and histamine content in blood,and showd highly signifieant compared with that of the normal group（P 0.01）.The treatment group with the Mahuang Fuzi Xixin decoction showd highly signifieant（P 0.01） in reducing histamine content in blood（3.64 ± 0.83） mg.L-1,compared with the Xiaoqinglong decoction group（4.58 ± 0.51） mg.L-1 and the Xinqin granules group（4.36 ± 0.13） mg.L-1,and also acted better on recovering the nasal mucosa.Conclusion：Mahuang Fuzi Xixin decoction is more effective in treaing EAR,and it acts better than the Xiaoqinglong decoction on ruducing histamine content in blood andrecovering the nasal mucosa.