“Schizophrenic”嵌段共聚物多重胶束化的研究

Schizophrenic Micellization of Block Copolymers

在不同环境刺激下自组装形成多重胶束的"schizophrenic"嵌段共聚物由于诱人的潜在应用而引起广泛的关注。本文综述了各种刺激诱导形成多重胶束的"schizophrenic"嵌段共聚物研究情况,介绍了多重胶束化不同形态的影响因素和胶束稳定方面的进展。并对"schizophrenic"嵌段共聚物的合成与表征技巧进行了总结,最后讨论了当前研究中仍需解决的问题,并对其应用前景做了展望。

The schizophrenic micellization of block copolymers who can self-assembled into well-defined structures in aqueous solution in response to specific stimuli such as temperature, pH, ionic strength and light has draw much attention due to the attractive protential applications. A typical case in this new sub-field involved environmental-sensitive AB diblock copolymer synthesized by group transfer polymerization （GTP） or living radical polymerisation （ATRP or RAFT）, allowing the formation of two distinct types of micelle structures （A-core / B- corona and B-core / A-corona structures） in response to external stimuli and the two structures can be reversibly converted into each other. This remarkable property was introduced by Armes and coworkers for ＇smart＇ pH- dependent micelles of poly [ 2- （diethylamino） ethyl methacrylate ~ -block- poly [ 2- （N-morpholino） ethyl meth- acrylate ]. Recent progress in synthesis and environmental-induced schizophrenic micellization of block copolymers, the morphology of aggregations self-assembled from schizophrenic block copolymers and fixed structure of micelles by crosslinker have been reviewed. Technical problems in synthesis and characterization of schizophrenic micellization are also discussed, including 1H-NMR spectra, zeta potential, light scattering, transmittance of the solution and stopped-flow spectrophotometric techniques. Furthermore, the problems in schizophrenic micellization those still should be resolved are pointed out, and the direction of this research field is discussed.