华蟾素乳剂对小鼠Lewis肺癌的药效学研究

Experimental study of effects of Huachansu Parenteral Emulsion on Lewis lung carcinoma in mice

目的:研究华蟾素乳剂对实体肿瘤的疗效及其可能的作用机制。方法:本研究运用Lewis肺癌小鼠模型,观察华蟾素乳剂对小鼠Lewis肺癌的疗效、免疫功能的影响。结果:华蟾素乳剂治疗小鼠Lewis肺癌能抑制肿瘤的生长,抑瘤率高达32.7%,稳定病灶,提高荷瘤小鼠的生存质量,明显提高校正廓清指数α(P<0.01)以及溶血素水平(P<0.05),改善免疫功能。结论:华蟾素乳剂对小鼠Lewis肺癌有明显疗效,其作用机制与其本身对Lewis肺癌实体瘤有抑制作用和提高荷瘤小鼠免疫功能有关。

Objective：To study the therapeutic effects of Huachansu Parenteral Emulsion（HCSPE） in mice and possible mechanism.Methods：The mice with Lewis lung carcinoma was used as a model for observing the therapeutic effect,the immunomodulatory functions,and changes of quality of life.Results：HCSPE inhibited the growth of tumor as the tumor inhibition ratio of 32.7%,enhanced clearance index α（P〈0.01） and serum hemolysin level（P〈0.05） obviously,increased life quality and the immunity of mice with Lewis lung carcinoma.Conclusion：HCSPE has therapeutic effects in mice with Lewis lung carcinoma.It’s mechanism might be associated with improving the immunity of mice with Lewis lung carcinoma.